Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nrg1tm1Leth
Name:	neuregulin 1; targeted mutation 1, Lars E Theill
MGI ID:	MGI:1928491
Synonyms:	neuregulinIg, Nrg -
Gene:	Nrg1  Location: Chr8:32299493-33381858 bp, - strand  Genetic Position: Chr8, 18.75 cM
Alliance:	Nrg1tm1Leth page

Germline Transmission:	Earliest citation of germline transmission: J:33038
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Part of exon 3, encoding the Ig domain, was replaced with a PGK-neomycin cassette (J:33038)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:	53 strains or lines available

Original:	J:33038 Kramer R, et al., Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4833-8
All:	6 reference(s)