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Elf4 Gene Detail
Summary
  • Symbol
    Elf4
  • Name
    E74 like ETS transcription factor 4
  • Synonyms
    MEF, myeloid elf-1 like factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928377
    NCBI Gene: 56501
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:47499926-47552009 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 25.67 cM, cytoband A3.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928377
 protein coding gene ChrX:47499923-47552009 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035692
 protein coding gene ChrX:43572552-43625929 (-)
A/J MGP_AJ_G0035675
 protein coding gene ChrX:43428609-43483324 (-)
AKR/J MGP_AKRJ_G0035595
 protein coding gene ChrX:44631115-44693424 (-)
BALB/cJ MGP_BALBcJ_G0035661
 protein coding gene ChrX:43073311-43133908 (-)
C3H/HeJ MGP_C3HHeJ_G0035365
 protein coding gene ChrX:43860098-43915274 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036190
 protein coding gene ChrX:44593771-44651845 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033042
 protein coding gene ChrX:41120889-41172913 (-)
CAST/EiJ MGP_CASTEiJ_G0034656
 protein coding gene ChrX:31441317-31495967 (-)
CBA/J MGP_CBAJ_G0035339
 protein coding gene ChrX:45849376-45909963 (-)
DBA/2J MGP_DBA2J_G0035493
 protein coding gene ChrX:43269100-43321710 (-)
FVB/NJ MGP_FVBNJ_G0035442
 protein coding gene ChrX:42987837-43040077 (-)
LP/J MGP_LPJ_G0035581
 protein coding gene ChrX:43916920-43979534 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035480
 protein coding gene ChrX:47280484-47337398 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036208
 protein coding gene ChrX:43470373-43523595 (-)
PWK/PhJ MGP_PWKPhJ_G0034355
 protein coding gene ChrX:30918669-30973340 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034200
 protein coding gene ChrX:32228597-32284964 (-)
WSB/EiJ MGP_WSBEiJ_G0034800
 protein coding gene ChrX:43109635-43164996 (-)



Homology
more
  • Human Ortholog
    ELF4, E74 like ETS transcription factor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELF4, E74 like ETS transcription factor 4
  • Synonyms
    AIFBL2, ELFR, MEF
  • Links
    NCBI Gene ID: 2000
    neXtProt AC: NX_Q99607
    UniProt: Q99607

  • Chr Location
    Xq26.1; chrX:130063955-130111927 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have hematopoietic cells with impaired proliferative properties. Lymphocyte development and function is altered, particularly with respect to NK cells and NK-T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    973
  • Tissues
    169
  • cDNA Data
    30
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56501 NCBI Gene Model | MGI Sequence Detail 52084 C57BL/6J ±  kb
transcript NM_001381876 RefSeq | MGI Sequence Detail 6234 C57BL/6  
polypeptide Q9Z2U4 UniProt | EBI | MGI Sequence Detail 655 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    cDNA 31
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147984, MGI:2671002
References
more
  • Summaries
    All 66
    Developmental Gene Expression 11
    Gene Ontology 8
    Phenotypes 26
  • Earliest
    J:79568 Lacorazza HD, et al., The ETS Protein MEF Plays a Critical Role in Perforin Gene Expression and the Development of Natural Killer and NK-T Cells. Immunity. 2002 Oct;17(4):437
  • Latest
    J:341864 Li L, et al., Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress. BMC Mol Cell Biol. 2023 Jul 20;24(1):22
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory