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Sp5 Gene Detail
Summary
  • Symbol
    Sp5
  • Name
    trans-acting transcription factor 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927715
    NCBI Gene: 64406
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:70305267-70308070 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 41.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927715
 protein coding gene Chr2:70305267-70308073 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025811
 protein coding gene Chr2:70520120-70522923 (+)
A/J MGP_AJ_G0025788
 protein coding gene Chr2:67780275-67783042 (+)
AKR/J MGP_AKRJ_G0025757
 protein coding gene Chr2:69623439-69626206 (+)
BALB/cJ MGP_BALBcJ_G0025783
 protein coding gene Chr2:67966686-67969453 (+)
C3H/HeJ MGP_C3HHeJ_G0025543
 protein coding gene Chr2:69846384-69849151 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026230
 protein coding gene Chr2:72641812-72644612 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023633
 protein coding gene Chr2:65010366-65013114 (+)
CAST/EiJ MGP_CASTEiJ_G0025007
 protein coding gene Chr2:69996200-70000496 (+)
CBA/J MGP_CBAJ_G0025523
 protein coding gene Chr2:75337329-75340096 (+)
DBA/2J MGP_DBA2J_G0025654
 protein coding gene Chr2:67413658-67416425 (+)
FVB/NJ MGP_FVBNJ_G0025617
 protein coding gene Chr2:66785828-66788595 (+)
LP/J MGP_LPJ_G0025743
 protein coding gene Chr2:70363500-70366265 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025646
 protein coding gene Chr2:77361713-77364480 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026287
 protein coding gene Chr2:69717732-69720499 (+)
PWK/PhJ MGP_PWKPhJ_G0024748
 protein coding gene Chr2:67264060-67266927 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024555
 protein coding gene Chr2:69932515-69935275 (+)
WSB/EiJ MGP_WSBEiJ_G0025075
 protein coding gene Chr2:70151638-70154417 (+)



Homology
more
  • Human Ortholog
    SP5, Sp5 transcription factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SP5, Sp5 transcription factor
  • Links
    NCBI Gene ID: 389058
    neXtProt AC: NX_Q6BEB4
    UniProt: Q6BEB4

  • Chr Location
    2q31.1; chr2:170715337-170718078 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation in this gene are fertile and show no overt phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1061
  • Tissues
    180
  • cDNA Data
    12
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64406 NCBI Gene Model | MGI Sequence Detail 2804 C57BL/6J ±  kb
    transcript NM_022435 RefSeq | MGI Sequence Detail 2097 ZRU/MplStud  
    polypeptide Q9JHX2 UniProt | EBI | MGI Sequence Detail 398 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 14
      Primer pair 5
      Other 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 44
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:65743 Harrison SM, et al., Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury. Dev Biol. 2000 Nov 15;227(2):358-72
    • Latest
      J:344102 Racedo SE, et al., Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory