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Foxb1 Gene Detail
Summary
  • Symbol
    Foxb1
  • Name
    forkhead box B1
  • Synonyms
    C43, Fkh5, Foxb1a, Foxb1b, Hfh-e5.1, Mf3, TWH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927549
    NCBI Gene: 64290
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:69664992-69668222 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 38.76 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927549
 protein coding gene Chr9:69664992-69668222 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034993
 protein coding gene Chr9:69768160-69771385 (-)
A/J MGP_AJ_G0034974
 protein coding gene Chr9:67370231-67373451 (-)
AKR/J MGP_AKRJ_G0034903
 protein coding gene Chr9:68968990-68972220 (-)
BALB/cJ MGP_BALBcJ_G0034966
 protein coding gene Chr9:67093135-67096355 (-)
C3H/HeJ MGP_C3HHeJ_G0034675
 protein coding gene Chr9:69471186-69474406 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035485
 protein coding gene Chr9:71636660-71639890 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032396
 protein coding gene Chr9:66933531-66936739 (-)
CAST/EiJ MGP_CASTEiJ_G0033997
 protein coding gene Chr9:69734983-69738186 (-)
CBA/J MGP_CBAJ_G0034648
 protein coding gene Chr9:74141807-74145027 (-)
DBA/2J MGP_DBA2J_G0034807
 protein coding gene Chr9:67119460-67122679 (-)
FVB/NJ MGP_FVBNJ_G0034749
 protein coding gene Chr9:66437203-66440423 (-)
LP/J MGP_LPJ_G0034888
 protein coding gene Chr9:70017352-70020577 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034790
 protein coding gene Chr9:75238303-75241580 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035507
 protein coding gene Chr9:69108377-69111600 (-)
PWK/PhJ MGP_PWKPhJ_G0033701
 protein coding gene Chr9:67348228-67351456 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033534
 protein coding gene Chr9:69412567-69415781 (-)
WSB/EiJ MGP_WSBEiJ_G0034109
 protein coding gene Chr9:68992432-68995694 (-)



Homology
more
  • Human Ortholog
    FOXB1, forkhead box B1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXB1, forkhead box B1
  • Synonyms
    FKH5, HFKH-5
  • Links
    NCBI Gene ID: 27023
    neXtProt AC: NX_Q99853
    UniProt: Q99853

  • Chr Location
    15q22.2; chr15:60004234-60061730 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 5 alleles in 9 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted null mutant mice show variable embryonic lethality with neural tube defects or severe posterior reduction. Survivors have high postnatal mortality, reduced growth, motor weakness, midbrain abnormalities and females have a lactational defect.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1227
  • Tissues
    328
  • cDNA Data
    14
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64290 NCBI Gene Model | MGI Sequence Detail 3231 C57BL/6J ±  kb
    transcript NM_022378 RefSeq | MGI Sequence Detail 2984 Not Specified  
    polypeptide Q64732 UniProt | EBI | MGI Sequence Detail 325 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 5
      cDNA 16
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24019, MGD-MRK-39569, MGD-MRK-9817, MGI:103153, MGI:109570, MGI:1347486, MGI:95548
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 37
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:11921 Sasaki H, et al., Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development. 1993 May;118(1):47-59
    • Latest
      J:320531 Kucukerden M, et al., Compromised mammillary body connectivity and psychotic symptoms in mice with di- and mesencephalic ablation of ST8SIA2. Transl Psychiatry. 2022 Feb 3;12(1):51
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory