Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	H2-Ab1b-tm1Doi
Name:	histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Christophe Benoist and Diane Mathis
MGI ID:	MGI:1927483
Synonyms:	AB0, Abbeta-, Abeta-, A beta0, Class II0, H2-Ab1tm1Dim, H2-Ab1tm1Doi, H2-Ab1tm1Doi, II0, MHC class II-, MHCII-, MHC-II-k.o.
Gene:	H2-Ab1  Location: Chr17:34482201-34488392 bp, + strand  Genetic Position: Chr17, 17.98 cM
Alliance:	H2-Ab1b-tm1Doi page

Germline Transmission:	Earliest citation of germline transmission: J:65736
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The second exon was disrupted by the insertion of a neomycin resistance gene. In addition, the ES cell line used was derived from the 129S2/SvPas strain, which carries a deletion in the promoter region of H2-Ea. Consequently, these MHC class II molecule-deficient mice lacked cell surface expression of both class II-A and class II-E MHC proteins. (J:65736)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 24 strains available      Cell Lines: 0 lines available
Carrying any H2-Ab1 Mutation:	81 strains or lines available

Original:	J:65736 Cosgrove D, et al., Mice lacking MHC class II molecules. Cell. 1991 Sep 6;66(5):1051-66
All:	173 reference(s)