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Zbp1 Gene Detail
Summary
  • Symbol
    Zbp1
  • Name
    Z-DNA binding protein 1
  • Synonyms
    2010010H03Rik, Dai, mZaDLM
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927449
    NCBI Gene: 58203
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:173048405-173060715 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 95.83 cM, cytoband H3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927449
 protein coding gene Chr2:173048405-173060716 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026955
 protein coding gene Chr2:179466959-179478913 (-)
A/J MGP_AJ_G0026922
 protein coding gene Chr2:171919706-171931650 (-)
AKR/J MGP_AKRJ_G0026893
 protein coding gene Chr2:177104746-177116705 (-)
BALB/cJ MGP_BALBcJ_G0026931
 protein coding gene Chr2:172321120-172333450 (-)
C3H/HeJ MGP_C3HHeJ_G0026673
 protein coding gene Chr2:177494487-177506799 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027378
 protein coding gene Chr2:184627896-184644329 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024748
 protein coding gene Chr2:165155662-165167912 (-)
CAST/EiJ MGP_CASTEiJ_G0026131
 protein coding gene Chr2:178187214-178199200 (-)
CBA/J MGP_CBAJ_G0026650
 protein coding gene Chr2:191535387-191547803 (-)
DBA/2J MGP_DBA2J_G0026788
 protein coding gene Chr2:171012385-171024710 (-)
FVB/NJ MGP_FVBNJ_G0026754
 protein coding gene Chr2:169632795-169645388 (-)
LP/J MGP_LPJ_G0026889
 protein coding gene Chr2:179397892-179411222 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026773
 protein coding gene Chr2:194467402-194479715 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027435
 protein coding gene Chr2:177124708-177139114 (-)
PWK/PhJ MGP_PWKPhJ_G0025868
 protein coding gene Chr2:170808260-170821022 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025668
 protein coding gene Chr2:176128279-176140084 (-)
WSB/EiJ MGP_WSBEiJ_G0026204
 protein coding gene Chr2:178071702-178085332 (-)



Homology
more
  • Human Ortholog
    ZBP1, Z-DNA binding protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZBP1, Z-DNA binding protein 1
  • Synonyms
    C20orf183, DAI, DLM1, DLM-1
  • Links
    NCBI Gene ID: 81030
    neXtProt AC: NX_Q9H171
    UniProt: Q9H171

  • Chr Location
    20q13.31; chr20:57603846-57620576 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display normal innate immune activation by double-stranded B-form DNA (B-DNA) as well as normal adaptive immune responses to DNA vaccination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    6
  • cDNA Data
    36
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 58203 NCBI Gene Model | MGI Sequence Detail 12311 C57BL/6J ±  kb
transcript NM_021394 RefSeq | MGI Sequence Detail 1988 C57BL/6  
polypeptide Q9QY24 UniProt | EBI | MGI Sequence Detail 411 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 36
    cDNA 36

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917117
References
more
  • Summaries
    All 83
    Developmental Gene Expression 4
    Gene Ontology 22
    Phenotypes 40
  • Earliest
    J:58659 Fu Y, et al., Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display. Gene. 1999 Nov 15;240(1):157-63
  • Latest
    J:338214 Lei Y, et al., Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity. Cell. 2023 Jul 6;186(14):3013-3032.e22
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory