About   Help   FAQ
Dusp14 Gene Detail
Summary
  • Symbol
    Dusp14
  • Name
    dual specificity phosphatase 14
  • Synonyms
    1110014C10Rik, 2310042C07Rik, D11Ertd395e, Mkp6, MKP-L
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927168
    NCBI Gene: 56405
  • Alliance
  • Transcription Start Sites
    11 TSS
  • Candidate for QTL
    8 QTL
Location &
Maps
more
  • Sequence Map
    Chr11:83938859-83960016 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.29 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927168
protein coding gene Chr11:83938859-83960087 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018865
protein coding gene Chr11:85445933-85468860 (-)
A/J MGP_AJ_G0018832
protein coding gene Chr11:82199129-82221702 (-)
AKR/J MGP_AKRJ_G0018802
protein coding gene Chr11:84619891-84642389 (-)
BALB/cJ MGP_BALBcJ_G0018805
protein coding gene Chr11:82583888-82606068 (-)
C3H/HeJ MGP_C3HHeJ_G0018619
protein coding gene Chr11:84673537-84695668 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019257
protein coding gene Chr11:88031239-88054964 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016890
protein coding gene Chr11:79290246-79310092 (-)
CAST/EiJ MGP_CASTEiJ_G0018174
protein coding gene Chr11:85309449-85332154 (-)
CBA/J MGP_CBAJ_G0018590
protein coding gene Chr11:91808804-91830019 (-)
DBA/2J MGP_DBA2J_G0018698
protein coding gene Chr11:81776416-81798250 (-)
FVB/NJ MGP_FVBNJ_G0018687
protein coding gene Chr11:81247804-81269255 (-)
LP/J MGP_LPJ_G0018768
protein coding gene Chr11:85977506-85998805 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018714
protein coding gene Chr11:91955970-91981900 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019297
protein coding gene Chr11:84903635-84925845 (-)
PWK/PhJ MGP_PWKPhJ_G0017943
protein coding gene Chr11:82531486-82553612 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017735
protein coding gene Chr11:84440444-84464733 (-)
WSB/EiJ MGP_WSBEiJ_G0018225
protein coding gene Chr11:84748021-84769211 (-)



Homology
more
  • Human Ortholog
    DUSP14, dual specificity phosphatase 14
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DUSP14, dual specificity phosphatase 14
  • Synonyms
    MKP6, MKP-L
  • Links
    NCBI Gene ID: 11072
    neXtProt AC: NX_O95147
    UniProt: O95147

  • Chr Location
    17q12; chr17:37488566-37513501 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO results in increased T cell activation, proliferation and differentiation. It also causes increased cardiac hypertrophy in response to aortic banding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56405 NCBI Gene Model | MGI Sequence Detail 21158 C57BL/6J ±  kb
    transcript NM_001408746 RefSeq | MGI Sequence Detail 1578 ZRU/MplStud  
    polypeptide Q9JLY7 UniProt | EBI | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 14
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1196441, MGI:1915839, MGI:1917390
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 10
      Gene Ontology 4
      Phenotypes 22
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:334297 Warren EB, et al., 17q12 deletion syndrome mouse model shows defects in craniofacial, brain and kidney development, and glucose homeostasis. Dis Model Mech. 2022 Dec 1;15(12):dmm049752

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory