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Mettl3 Gene Detail
Summary
  • Symbol
    Mettl3
  • Name
    methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
  • Synonyms
    2310024F18Rik, M6A, Spo8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927165
    NCBI Gene: 56335
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:52532298-52542585 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.88 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927165
 protein coding gene Chr14:52532298-52548555 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021296
 protein coding gene Chr14:46332669-46344543 (-)
A/J MGP_AJ_G0021253
 protein coding gene Chr14:45111090-45121417 (-)
AKR/J MGP_AKRJ_G0021229
 protein coding gene Chr14:46745395-46758978 (-)
BALB/cJ MGP_BALBcJ_G0021257
 protein coding gene Chr14:45224814-45235195 (-)
C3H/HeJ MGP_C3HHeJ_G0021037
 protein coding gene Chr14:46548859-46559289 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021696
 protein coding gene Chr14:48389682-48400187 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019240
 protein coding gene Chr14:44317732-44327994 (-)
CAST/EiJ MGP_CASTEiJ_G0020556
 protein coding gene Chr14:43527492-43537963 (-)
CBA/J MGP_CBAJ_G0021004
 protein coding gene Chr14:49839657-49853297 (-)
DBA/2J MGP_DBA2J_G0021125
 protein coding gene Chr14:44886672-44897271 (-)
FVB/NJ MGP_FVBNJ_G0021108
 protein coding gene Chr14:44472748-44483211 (-)
LP/J MGP_LPJ_G0021200
 protein coding gene Chr14:46924799-46937528 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021131
 protein coding gene Chr14:49289154-49300611 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021723
 protein coding gene Chr14:46125375-46135725 (-)
PWK/PhJ MGP_PWKPhJ_G0020305
 protein coding gene Chr14:41627645-41638469 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020132
 protein coding gene Chr14:42166263-42176704 (-)
WSB/EiJ MGP_WSBEiJ_G0020609
 protein coding gene Chr14:46456138-46466632 (-)



Homology
more
  • Human Ortholog
    METTL3, methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL3, methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
  • Synonyms
    hMETTL3, IME4, M6A, MT-A70, Spo8
  • Links
    NCBI Gene ID: 56339
    neXtProt AC: NX_Q86U44
    UniProt: Q86U44

  • Chr Location
    14q11.2; chr14:21498133-21511342 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 9 genetic backgrounds
    14 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality between E3.5 and E8.5 with a deficiency in adopting the epiblast egg cylinder. Conditional homozygous knockout in the ovary or in primordial germ cells in testes causes sterility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    23
  • cDNA Data
    13
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022160 Ensembl Gene Model | MGI Sequence Detail 10288 C57BL/6J ±  kb
    transcript ENSMUST00000022767 Ensembl | MGI Sequence Detail 2025 Not Applicable  
    polypeptide ENSMUSP00000022767 Ensembl | MGI Sequence Detail 580 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1916819
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 13
      Gene Ontology 20
      Phenotypes 59
    • Earliest
      J:70548 Bokar JA, et al., Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA. 1997 Nov;3(11):1233-47
    • Latest
      J:346277 Yin H, et al., Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer's disease pathology in mice. PLoS Biol. 2023 Mar;21(3):e3002017
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory