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Kcnq1ot1 Gene Detail
Summary
  • Symbol
    Kcnq1ot1
  • Name
    KCNQ1 overlapping transcript 1
  • Synonyms
    Kvlqt1-as, Lit1, Tssc8
  • Feature Type
    lncRNA gene
  • IDs
    MGI:1926855
    NCBI Gene: 63830
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:142766848-142850284 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 88.15 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    476 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926855
 lncRNA gene Chr7:142731562-142850286 (-)
129S1/SvImJ MGP_129S1SvImJ_G0004525
 antisense lncRNA gene Chr7:148501128-148581252 (-)
A/J MGP_AJ_G0004505
 antisense lncRNA gene Chr7:144194988-144279146 (-)
AKR/J MGP_AKRJ_G0004488
 antisense lncRNA gene Chr7:148245318-148329911 (-)
BALB/cJ MGP_BALBcJ_G0004490
 antisense lncRNA gene Chr7:143971895-144061794 (-)
C3H/HeJ MGP_C3HHeJ_G0004439
 antisense lncRNA gene Chr7:148007446-148093893 (-)
C57BL/6NJ MGP_C57BL6NJ_G0004640
 antisense lncRNA gene Chr7:153865226-153958929 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0004094
 antisense lncRNA gene Chr7:145409242-145489715 (-)
CAST/EiJ MGP_CASTEiJ_G0004399
 antisense lncRNA gene Chr7:140311752-140398676 (-)
CBA/J MGP_CBAJ_G0004434
 antisense lncRNA gene Chr7:159129029-159213362 (-)
DBA/2J MGP_DBA2J_G0004448
 antisense lncRNA gene Chr7:142168455-142251232 (-)
FVB/NJ MGP_FVBNJ_G0004465
 antisense lncRNA gene Chr7:142093325-142178121 (-)
LP/J MGP_LPJ_G0004529
 antisense lncRNA gene Chr7:150025760-150117515 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0004454
 antisense lncRNA gene Chr7:159712398-159811741 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0004639
 antisense lncRNA gene Chr7:147210806-147293388 (-)
PWK/PhJ MGP_PWKPhJ_G0004352
 antisense lncRNA gene Chr7:135474127-135562977 (-)
SPRET/EiJ MGP_SPRETEiJ_G0004293
 antisense lncRNA gene Chr7:134015576-134105281 (-)
WSB/EiJ MGP_WSBEiJ_G0004438
 antisense lncRNA gene Chr7:148215047-148296153 (-)



Homology
more
  • Human Ortholog
    KCNQ1OT1, KCNQ1 opposite strand/antisense transcript 1
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNQ1OT1, KCNQ1 opposite strand/antisense transcript 1
  • Synonyms
    KCNQ10T1, KCNQ1-AS2, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012
  • Links
    NCBI Gene ID: 10984

  • Chr Location
    11p15.5; chr11:2597308-2700003 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KCNQ1OT1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 9 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for any of several independently generated targeted alleles exhibit abnormal imprinting and may display a growth deficiency.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    7
  • cDNA Data
    24
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      56
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 63830 NCBI Gene Model | MGI Sequence Detail 83437 C57BL/6J ±  kb
    transcript NR_001461 RefSeq | MGI Sequence Detail 83437 ZRU/MplStud  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 25
      Primer pair 8

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1930304
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 29
      Gene Ontology 4
      Phenotypes 18
    • Earliest
      J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
    • Latest
      J:306451 Yu XH, et al., LncRNA kcnq1ot1 promotes lipid accumulation and accelerates atherosclerosis via functioning as a ceRNA through the miR-452-3p/HDAC3/ABCA1 axis. Cell Death Dis. 2020 Dec 9;11(12):1043
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory