Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Itgb6tm1Des Name: integrin beta 6; targeted mutation 1, Dean Sheppard MGI ID: MGI:1926484 Synonyms: beta6-, Itgb6- Gene: Itgb6  Location: Chr2:60428636-60552987 bp, - strand  Genetic Position: Chr2, 34.81 cM, cytoband C3 Alliance: Itgb6tm1Des page

Juvenile baldness in Itgb6tm1Des/Itgb6tm1Des mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:33139
Parent Cell Line:	RF8 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion     Insertion of a neomycin gene into a coding exon of the Itgb6 gene. (J:33139)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

List all tumor models in MMHCdb carrying Itgb6tm1Des

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb6 Mutation:	31 strains or lines available

Original:	J:33139 Huang XZ, et al., Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol. 1996 May;133(4):921-8
All:	35 reference(s)