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Fbxo43 Gene Detail
Summary
  • Symbol
    Fbxo43
  • Name
    F-box protein 43
  • Synonyms
    4930533G20Rik, early mitotic inhibitor 2, Emi2, endogenous meiotic inhibitor 2, XErp1 homolog
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926053
    NCBI Gene: 78803
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:36150206-36165030 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 14.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926053
 protein coding gene Chr15:36150206-36170086 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021790
 protein coding gene Chr15:34529687-34544583 (-)
A/J MGP_AJ_G0021751
 protein coding gene Chr15:33231892-33246717 (-)
AKR/J MGP_AKRJ_G0021729
 protein coding gene Chr15:34151466-34166435 (-)
BALB/cJ MGP_BALBcJ_G0021757
 protein coding gene Chr15:33237670-33252479 (-)
C3H/HeJ MGP_C3HHeJ_G0021532
 protein coding gene Chr15:34121276-34136082 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022196
 protein coding gene Chr15:35835299-35850164 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019734
 protein coding gene Chr15:31044950-31059092 (-)
CAST/EiJ MGP_CASTEiJ_G0021048
 protein coding gene Chr15:34524132-34538698 (-)
CBA/J MGP_CBAJ_G0021501
 protein coding gene Chr15:36994400-37009215 (-)
DBA/2J MGP_DBA2J_G0021625
 protein coding gene Chr15:33054412-33069210 (-)
FVB/NJ MGP_FVBNJ_G0021603
 protein coding gene Chr15:32453923-32468715 (-)
LP/J MGP_LPJ_G0021694
 protein coding gene Chr15:34431810-34446686 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021628
 protein coding gene Chr15:40107262-40125414 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022219
 protein coding gene Chr15:34306245-34321065 (-)
PWK/PhJ MGP_PWKPhJ_G0020792
 protein coding gene Chr15:33071915-33087111 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020630
 protein coding gene Chr15:34004349-34019073 (-)
WSB/EiJ MGP_WSBEiJ_G0021104
 protein coding gene Chr15:34273916-34288695 (-)



Homology
more
  • Human Ortholog
    FBXO43, F-box protein 43
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXO43, F-box protein 43
  • Synonyms
    EMI2, ERP1, FBX43, OOMD12, OZEMA12, SPGF64
  • Links
    NCBI Gene ID: 286151
    neXtProt AC: NX_Q4G163
    UniProt: Q4G163

  • Chr Location
    8q22.2; chr8:100133351-100150569 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FBXO43 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit female and male infertility with arrested meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    18
  • cDNA Data
    14
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048230 Ensembl Gene Model | MGI Sequence Detail 14825 C57BL/6J ±  kb
    transcript ENSMUST00000058643 Ensembl | MGI Sequence Detail 4035 Not Applicable  
    polypeptide ENSMUSP00000054125 Ensembl | MGI Sequence Detail 641 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345099 Wang X, et al., Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development. BMC Genomics. 2024 Feb 3;25(1):139
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory