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Acap2 Gene Detail
Summary
  • Symbol
    Acap2
  • Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
  • Synonyms
    9530039J15Rik, Centb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925868
    NCBI Gene: 78618
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:30911230-31020063 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 21.34 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    623 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925868
protein coding gene Chr16:30911230-31020105 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022717
protein coding gene Chr16:29035217-29150562 (-)
A/J MGP_AJ_G0022680
protein coding gene Chr16:27693033-27803643 (-)
AKR/J MGP_AKRJ_G0022654
protein coding gene Chr16:28742477-28863118 (-)
BALB/cJ MGP_BALBcJ_G0022684
protein coding gene Chr16:27873682-27984507 (-)
C3H/HeJ MGP_C3HHeJ_G0022449
protein coding gene Chr16:28844469-28956461 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023133
protein coding gene Chr16:29673774-29796552 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020651
protein coding gene Chr16:28122893-28231592 (-)
CAST/EiJ MGP_CASTEiJ_G0021977
protein coding gene Chr16:28963558-29074390 (-)
CBA/J MGP_CBAJ_G0022419
protein coding gene Chr16:30917629-31038660 (-)
DBA/2J MGP_DBA2J_G0022552
protein coding gene Chr16:27571400-27679485 (-)
FVB/NJ MGP_FVBNJ_G0022527
protein coding gene Chr16:27548122-27657064 (-)
LP/J MGP_LPJ_G0022619
protein coding gene Chr16:28842651-28959593 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022546
protein coding gene Chr16:30407044-30517935 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023145
protein coding gene Chr16:28695240-28809309 (-)
PWK/PhJ MGP_PWKPhJ_G0021716
protein coding gene Chr16:27886704-27993210 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021547
protein coding gene Chr16:28471815-28583758 (-)
WSB/EiJ MGP_WSBEiJ_G0022021
protein coding gene Chr16:28650351-28756911 (-)



Homology
more
  • Human Ortholog
    ACAP2, ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACAP2, ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
  • Synonyms
    CENTB2, CNT-B2
  • Links
    NCBI Gene ID: 23527
    neXtProt AC: NX_Q15057
    UniProt: Q15057

  • Chr Location
    3q29; chr3:195274745-195443044 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049076 Ensembl Gene Model | MGI Sequence Detail 108834 C57BL/6J ±  kb
transcript ENSMUST00000229010 Ensembl | MGI Sequence Detail 2810 Not Applicable  
polypeptide ENSMUSP00000156077 Ensembl | MGI Sequence Detail 805 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 93
    cDNA 92
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:65271 Dowler S, et al., Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J. 2000 Oct 1;351(Pt 1):19-31
  • Latest
    J:245108 Miura Y, et al., ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons. Biochem J. 2016 Sep 01;473(17):2591-602

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory