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Cox7b2 Gene Detail
Summary
  • Symbol
    Cox7b2
  • Name
    cytochrome c oxidase subunit 7B2
  • Synonyms
    4930503B16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925424
    NCBI Gene: 78174
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:71600167-71705548 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 37.98 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    247 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925424
protein coding gene Chr5:71600166-71705548 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029607
protein coding gene Chr5:71319523-71432994 (-)
A/J MGP_AJ_G0029575
protein coding gene Chr5:68655401-68758804 (-)
AKR/J MGP_AKRJ_G0029523
protein coding gene Chr5:70853975-70963425 (-)
BALB/cJ MGP_BALBcJ_G0029584
protein coding gene Chr5:69337391-69440596 (-)
C3H/HeJ MGP_C3HHeJ_G0029307
protein coding gene Chr5:71215561-71329751 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030038
protein coding gene Chr5:74305146-74420532 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027278
protein coding gene Chr5:64420787-64522735 (-)
CAST/EiJ MGP_CASTEiJ_G0028715
protein coding gene Chr5:70347703-70456454 (-)
CBA/J MGP_CBAJ_G0029276
protein coding gene Chr5:76673136-76793467 (-)
DBA/2J MGP_DBA2J_G0029422
protein coding gene Chr5:68726726-68825659 (-)
FVB/NJ MGP_FVBNJ_G0029382
protein coding gene Chr5:67897531-68001868 (-)
LP/J MGP_LPJ_G0029507
protein coding gene Chr5:71792163-71898219 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029410
protein coding gene Chr5:80022746-80156652 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030071
protein coding gene Chr5:70439763-70550502 (-)
PWK/PhJ MGP_PWKPhJ_G0028439
protein coding gene Chr5:67694080-67790883 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028273
protein coding gene Chr5:69802499-69912631 (-)
WSB/EiJ MGP_WSBEiJ_G0028795
protein coding gene Chr5:70699279-70804414 (-)



Homology
more
  • Human Ortholog
    COX7B2, cytochrome c oxidase subunit 7B2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX7B2, cytochrome c oxidase subunit 7B2
  • Links
    NCBI Gene ID: 170712
    neXtProt AC: NX_Q8TF08
    UniProt: Q8TF08

  • Chr Location
    4p12; chr4:46734827-46909245 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired sperm fertilization, asthenozoospermia, tetratozoospermia, and disorganized midpiece mitochondria.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049387 Ensembl Gene Model | MGI Sequence Detail 105382 C57BL/6J ±  kb
    transcript ENSMUST00000050129 Ensembl | MGI Sequence Detail 542 Not Applicable  
    polypeptide ENSMUSP00000060890 Ensembl | MGI Sequence Detail 82 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005790 cytochrome c oxidase subunit 7B2, mitochondrial
    • InterPro Domains
      IPR008433 Cytochrome C oxidase, subunit VIIB
      IPR023272 Cytochrome C oxidase, subunit VIIB domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 19
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:308859 Akter MS, et al., CRISPR/Cas9-based genetic screen of SCNT-reprogramming resistant genes identifies critical genes for male germ cell development in mice. Sci Rep. 2021 Jul 29;11(1):15438

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory