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Rnf170 Gene Detail
Summary
  • Symbol
    Rnf170
  • Name
    ring finger protein 170
  • Synonyms
    6720407G21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924983
    NCBI Gene: 77733
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:26609396-26633903 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 14.38 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924983
 protein coding gene Chr8:26609396-26641818 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033496
 protein coding gene Chr8:24214610-24239550 (+)
A/J MGP_AJ_G0033476
 protein coding gene Chr8:23326297-23351116 (+)
AKR/J MGP_AKRJ_G0033401
 protein coding gene Chr8:24095382-24122243 (+)
BALB/cJ MGP_BALBcJ_G0033472
 protein coding gene Chr8:23475731-23500449 (+)
C3H/HeJ MGP_C3HHeJ_G0033186
 protein coding gene Chr8:24304586-24331127 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033988
 protein coding gene Chr8:25194120-25223588 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030938
 protein coding gene Chr8:20598051-20621998 (+)
CAST/EiJ MGP_CASTEiJ_G0032512
 protein coding gene Chr8:23759255-23784140 (+)
CBA/J MGP_CBAJ_G0033161
 protein coding gene Chr8:26173658-26199573 (+)
DBA/2J MGP_DBA2J_G0033316
 protein coding gene Chr8:23292580-23317252 (+)
FVB/NJ MGP_FVBNJ_G0033260
 protein coding gene Chr8:23103790-23129218 (+)
LP/J MGP_LPJ_G0033405
 protein coding gene Chr8:24193631-24218980 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033303
 protein coding gene Chr8:25620870-25642897 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034007
 protein coding gene Chr8:24047340-24070894 (+)
PWK/PhJ MGP_PWKPhJ_G0032223
 protein coding gene Chr8:22937326-22961346 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032057
 protein coding gene Chr8:23422417-23446904 (+)
WSB/EiJ MGP_WSBEiJ_G0032628
 protein coding gene Chr8:24254417-24280844 (+)



Homology
more
  • Human Ortholog
    RNF170, ring finger protein 170
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF170, ring finger protein 170
  • Synonyms
    ADSA, SNAX1, SPG85
  • Links
    NCBI Gene ID: 81790
    neXtProt AC: NX_Q96K19
    UniProt: Q96K19

  • Chr Location
    8p11.21; chr8:42849637-42897299 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rnf170 mouse models; 2 with human RNF170 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele develop progressive gait abnormalities that are more pronounced in dark conditions with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77733 NCBI Gene Model | MGI Sequence Detail 24508 C57BL/6J ±  kb
    transcript NM_001357294 RefSeq | MGI Sequence Detail 4035 C57BL/6  
    polypeptide Q8CBG9 UniProt | EBI | MGI Sequence Detail 286 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 51

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142571
    References
    more
    • Summaries
      All 29
      Diseases 1
      Gene Ontology 4
      Phenotypes 2
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:315640 Song X, et al., E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells. Cell Mol Immunol. 2020 Aug;17(8):865-874
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory