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Tmem116 Gene Detail
Summary
  • Symbol
    Tmem116
  • Name
    transmembrane protein 116
  • Synonyms
    4930406A18Rik, 4930513P12Rik, C030022K24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924712
    NCBI Gene: 77462
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:121590643-121656601 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 61.81 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924712
protein coding gene Chr5:121589956-121662246 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030028
protein coding gene Chr5:124936878-125017001 (+)
A/J MGP_AJ_G0029993
protein coding gene Chr5:119793700-119868089 (+)
AKR/J MGP_AKRJ_G0029930
protein coding gene Chr5:123669028-123744410 (+)
BALB/cJ MGP_BALBcJ_G0030004
protein coding gene Chr5:121177264-121254590 (+)
C3H/HeJ MGP_C3HHeJ_G0029722
protein coding gene Chr5:124233323-124312300 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030457
protein coding gene Chr5:129696164-129775409 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027683
protein coding gene Chr5:114475029-114536357 (+)
CAST/EiJ MGP_CASTEiJ_G0029130
protein coding gene Chr5:123345766-123421923 (+)
CBA/J MGP_CBAJ_G0029691
protein coding gene Chr5:134793850-134880026 (+)
DBA/2J MGP_DBA2J_G0029841
protein coding gene Chr5:119864872-119937474 (+)
FVB/NJ MGP_FVBNJ_G0029798
protein coding gene Chr5:118812893-118892892 (+)
LP/J MGP_LPJ_G0029930
protein coding gene Chr5:125454782-125530538 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029828
protein coding gene Chr5:138653435-138731758 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030498
protein coding gene Chr5:123184317-123266154 (+)
PWK/PhJ MGP_PWKPhJ_G0028844
protein coding gene Chr5:118635601-118714170 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028681
protein coding gene Chr5:120949420-121024370 (+)
WSB/EiJ MGP_WSBEiJ_G0029205
protein coding gene Chr5:123840093-123920443 (+)



Homology
more
  • Human Ortholog
    TMEM116, transmembrane protein 116
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM116, transmembrane protein 116
  • Links
    NCBI Gene ID: 89894
    neXtProt AC: NX_Q8NCL8
    UniProt: Q8NCL8

  • Chr Location
    12q24.13; chr12:111931282-112013219 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77462 NCBI Gene Model | MGI Sequence Detail 65959 C57BL/6J ±  kb
    transcript NM_001161627 RefSeq | MGI Sequence Detail 1364 C57BL/6  
    polypeptide NP_001155099 RefSeq | MGI Sequence Detail 364 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • InterPro Domains
      IPR022343 GCR1-cAMP receptor
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918908, MGI:1921049
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 13
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:314587 Zhang S, et al., TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway. Cell Death Dis. 2021 Nov 16;12(12):1086

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory