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Spring1 Gene Detail
Summary
  • Symbol
    Spring1
  • Name
    SREBF pathway regulator in golgi 1
  • Synonyms
    2410131K14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924042
    NCBI Gene: 76792
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:118383292-118401179 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 58.32 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924042
 protein coding gene Chr5:118383292-118404158 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029996
 protein coding gene Chr5:121404118-121427825 (+)
A/J MGP_AJ_G0029960
 protein coding gene Chr5:116441092-116462064 (+)
AKR/J MGP_AKRJ_G0029899
 protein coding gene Chr5:120201631-120222630 (+)
BALB/cJ MGP_BALBcJ_G0029971
 protein coding gene Chr5:117864906-117886793 (+)
C3H/HeJ MGP_C3HHeJ_G0029691
 protein coding gene Chr5:120736014-120758576 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030426
 protein coding gene Chr5:126007311-126029231 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027652
 protein coding gene Chr5:111199091-111220269 (+)
CAST/EiJ MGP_CASTEiJ_G0029100
 protein coding gene Chr5:119751168-119772551 (+)
CBA/J MGP_CBAJ_G0029659
 protein coding gene Chr5:130861949-130887915 (+)
DBA/2J MGP_DBA2J_G0029809
 protein coding gene Chr5:116542424-116563557 (+)
FVB/NJ MGP_FVBNJ_G0029765
 protein coding gene Chr5:115437500-115458505 (+)
LP/J MGP_LPJ_G0029897
 protein coding gene Chr5:121892130-121915837 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029796
 protein coding gene Chr5:135030450-135051382 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030467
 protein coding gene Chr5:119754869-119776545 (+)
PWK/PhJ MGP_PWKPhJ_G0028813
 protein coding gene Chr5:115253867-115276218 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028651
 protein coding gene Chr5:117345721-117366843 (+)
WSB/EiJ MGP_WSBEiJ_G0029175
 protein coding gene Chr5:120328634-120353206 (+)



Homology
more
  • Human Ortholog
    SPRING1, SREBF pathway regulator in golgi 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPRING1, SREBF pathway regulator in golgi 1
  • Synonyms
    C12orf49, LUR1, POST1, SPRING
  • Links
    NCBI Gene ID: 79794
    neXtProt AC: NX_Q9H741
    UniProt: Q9H741

  • Chr Location
    12q24.22; chr12:116710171-116738070 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    1
  • cDNA Data
    28
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76792 NCBI Gene Model | MGI Sequence Detail 17888 C57BL/6J ±  kb
    transcript NM_001081236 RefSeq | MGI Sequence Detail 2670 Not Specified  
    polypeptide Q8BTG6 UniProt | EBI | MGI Sequence Detail 205 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 4
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 15
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:339682 Hendrix S, et al., Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans. Nat Commun. 2023 Aug 25;14(1):5181
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory