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Tufm Gene Detail
Summary
  • Symbol
    Tufm
  • Name
    Tu translation elongation factor, mitochondrial
  • Synonyms
    2300002G02Rik, C76308, EF-TuMT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923686
    NCBI Gene: 233870
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126086533-126089903 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923686
 protein coding gene Chr7:126086445-126089903 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032982
 protein coding gene Chr7:130765758-130769128 (+)
A/J MGP_AJ_G0032965
 protein coding gene Chr7:127308087-127311671 (+)
AKR/J MGP_AKRJ_G0032897
 protein coding gene Chr7:130529692-130533099 (+)
BALB/cJ MGP_BALBcJ_G0032970
 protein coding gene Chr7:126964544-126968586 (+)
C3H/HeJ MGP_C3HHeJ_G0032680
 protein coding gene Chr7:130455876-130459993 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033476
 protein coding gene Chr7:135851569-135857074 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030448
 protein coding gene Chr7:128502633-128506097 (+)
CAST/EiJ MGP_CASTEiJ_G0032008
 protein coding gene Chr7:122242718-122246137 (+)
CBA/J MGP_CBAJ_G0032653
 protein coding gene Chr7:140429114-140433322 (+)
DBA/2J MGP_DBA2J_G0032805
 protein coding gene Chr7:125280835-125287473 (+)
FVB/NJ MGP_FVBNJ_G0032758
 protein coding gene Chr7:125132385-125135920 (+)
LP/J MGP_LPJ_G0032899
 protein coding gene Chr7:132233081-132236538 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032791
 protein coding gene Chr7:141617011-141620589 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033496
 protein coding gene Chr7:129546451-129549821 (+)
PWK/PhJ MGP_PWKPhJ_G0031716
 protein coding gene Chr7:118267756-118271126 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031562
 protein coding gene Chr7:116364513-116367912 (+)
WSB/EiJ MGP_WSBEiJ_G0032121
 protein coding gene Chr7:130512659-130516030 (+)



Homology
more
  • Human Ortholog
    TUFM, Tu translation elongation factor, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUFM, Tu translation elongation factor, mitochondrial
  • Synonyms
    COXPD4, EFTU, EF-TuMT, P43
  • Links
    NCBI Gene ID: 7284
    neXtProt AC: NX_P49411
    UniProt: P49411

  • Chr Location
    16p11.2; chr16:28842411-28846348 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TUFM associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    81
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000073838 Ensembl Gene Model | MGI Sequence Detail 3371 C57BL/6J ±  kb
transcript ENSMUST00000098048 Ensembl | MGI Sequence Detail 1679 Not Applicable  
polypeptide ENSMUSP00000095656 Ensembl | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016832 elongation factor Tu, mitochondrial
    (term hierarchy)
  • InterPro Domains
    IPR033720 Elongation factor Tu, domain 2
    IPR041709 Elongation factor Tu (EF-Tu), GTP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000795 Translational (tr)-type GTP-binding domain
    IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle
    IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
    IPR004161 Translation elongation factor EFTu-like, domain 2
    IPR009000 Translation protein, beta-barrel domain superfamily
    IPR031157 Tr-type G domain, conserved site
Molecular
Reagents
less
  • All nucleic 81
    cDNA 81

    Microarray probesets 6
Other
Accession IDs
less
MGI:2142303, MGI:2142305
References
more
  • Summaries
    All 46
    Developmental Gene Expression 1
    Gene Ontology 12
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345336 Bi Y, et al., FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM. Cell Death Dis. 2022 Dec 5;13(12):1020
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory