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Cavin3 Gene Detail
Summary
  • Symbol
    Cavin3
  • Name
    caveolae associated 3
  • Synonyms
    3110015B12Rik, 6330514M23Rik, cavin 3, Prkcdbp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923422
    NCBI Gene: 109042
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:105129823-105131404 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.87 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923422
 protein coding gene Chr7:105129290-105131507 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032753
 protein coding gene Chr7:108730782-108732372 (-)
A/J MGP_AJ_G0032733
 protein coding gene Chr7:105887199-105888789 (-)
AKR/J MGP_AKRJ_G0032666
 protein coding gene Chr7:108659758-108661348 (-)
BALB/cJ MGP_BALBcJ_G0032739
 protein coding gene Chr7:105604555-105606145 (-)
C3H/HeJ MGP_C3HHeJ_G0032448
 protein coding gene Chr7:108753238-108754828 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033244
 protein coding gene Chr7:113069577-113071167 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030228
 protein coding gene Chr7:107867921-107869523 (-)
CAST/EiJ MGP_CASTEiJ_G0031778
 protein coding gene Chr7:100586170-100587802 (-)
CBA/J MGP_CBAJ_G0032422
 protein coding gene Chr7:116831986-116833576 (-)
DBA/2J MGP_DBA2J_G0032575
 protein coding gene Chr7:104159441-104161031 (-)
FVB/NJ MGP_FVBNJ_G0032528
 protein coding gene Chr7:103966459-103968049 (-)
LP/J MGP_LPJ_G0032666
 protein coding gene Chr7:110131146-110132736 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032560
 protein coding gene Chr7:118439262-118442525 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033265
 protein coding gene Chr7:107717090-107718680 (-)
PWK/PhJ MGP_PWKPhJ_G0031491
 protein coding gene Chr7:97093555-97095196 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031340
 protein coding gene Chr7:94835301-94836903 (-)
WSB/EiJ MGP_WSBEiJ_G0031895
 protein coding gene Chr7:108348774-108350376 (-)



Homology
more
  • Human Ortholog
    CAVIN3, caveolae associated protein 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAVIN3, caveolae associated protein 3
  • Synonyms
    cavin-3, HSRBC, PRKCDBP, SRBC
  • Links
    NCBI Gene ID: 112464
    neXtProt AC: NX_Q969G5
    UniProt: Q969G5

  • Chr Location
    11p15.4; chr11:6318946-6320532 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body weight, severe lipodystrophy, hepatic steatosis, increased fermentative glycolysis in lung tissue, and premature death as a result of cachexia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    29
  • cDNA Data
    63
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109042 NCBI Gene Model | MGI Sequence Detail 1582 C57BL/6J ±  kb
    transcript NM_028444 RefSeq | MGI Sequence Detail 1026 Not Specified  
    polypeptide Q91VJ2 UniProt | EBI | MGI Sequence Detail 260 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 63

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920378
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:325730 Ahuja N, et al., Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory