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Rasd2 Gene Detail
Summary
  • Symbol
    Rasd2
  • Name
    RASD family, member 2
  • Synonyms
    4930526B11Rik, Rhes, TEM2, TEM-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922391
    NCBI Gene: 75141
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:75940572-75950741 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 35.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922391
 protein coding gene Chr8:75940572-75950741 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033797
 protein coding gene Chr8:75663870-75674106 (+)
A/J MGP_AJ_G0033779
 protein coding gene Chr8:72693205-72703492 (+)
AKR/J MGP_AKRJ_G0033706
 protein coding gene Chr8:74910882-74920988 (+)
BALB/cJ MGP_BALBcJ_G0033773
 protein coding gene Chr8:72786102-72796442 (+)
C3H/HeJ MGP_C3HHeJ_G0033482
 protein coding gene Chr8:75475168-75485443 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034293
 protein coding gene Chr8:78595366-78610735 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031234
 protein coding gene Chr8:66955877-66965868 (+)
CAST/EiJ MGP_CASTEiJ_G0032811
 protein coding gene Chr8:74748424-74762514 (+)
CBA/J MGP_CBAJ_G0033461
 protein coding gene Chr8:81363680-81373896 (+)
DBA/2J MGP_DBA2J_G0033615
 protein coding gene Chr8:72379100-72389332 (+)
FVB/NJ MGP_FVBNJ_G0033560
 protein coding gene Chr8:71453683-71463606 (+)
LP/J MGP_LPJ_G0033704
 protein coding gene Chr8:75797456-75807667 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033603
 protein coding gene Chr8:83912178-83922410 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034310
 protein coding gene Chr8:74871060-74881299 (+)
PWK/PhJ MGP_PWKPhJ_G0032517
 protein coding gene Chr8:71648280-71658558 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032355
 protein coding gene Chr8:73753585-73768781 (+)
WSB/EiJ MGP_WSBEiJ_G0032926
 protein coding gene Chr8:75190401-75200623 (+)



Homology
more
  • Human Ortholog
    RASD2, RASD family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASD2, RASD family member 2
  • Synonyms
    Rhes, TEM2
  • Links
    NCBI Gene ID: 23551
    neXtProt AC: NX_Q96D21
    UniProt: Q96D21

  • Chr Location
    22q12.3; chr22:35532806-35553999 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display reduced body weight, impaired motor coordination, hypoactivity, and a gender-dependent increase in anxiety levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    22
  • cDNA Data
    15
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75141 NCBI Gene Model | MGI Sequence Detail 10170 C57BL/6J ±  kb
    transcript NM_029182 RefSeq | MGI Sequence Detail 2810 C57BL/6  
    polypeptide P63032 UniProt | EBI | MGI Sequence Detail 266 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 4
      cDNA 15
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142722
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:311740 Heikkinen T, et al., Global Rhes knockout in the Q175 Huntington's disease mouse model. PLoS One. 2021;16(10):e0258486
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory