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Rnase10 Gene Detail
Summary
  • Symbol
    Rnase10
  • Name
    ribonuclease, RNase A family, 10 (non-active)
  • Synonyms
    4930474F22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922269
    NCBI Gene: 75019
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51245208-51248215 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.34 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922269
 protein coding gene Chr14:51245208-51248218 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021266
 protein coding gene Chr14:44949610-44952617 (+)
A/J MGP_AJ_G0021220
 protein coding gene Chr14:43608505-43611512 (+)
AKR/J MGP_AKRJ_G0021196
 protein coding gene Chr14:45256829-45259836 (+)
BALB/cJ MGP_BALBcJ_G0021223
 protein coding gene Chr14:43725286-43728293 (+)
C3H/HeJ MGP_C3HHeJ_G0021005
 protein coding gene Chr14:45079303-45082310 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021660
 protein coding gene Chr14:46816468-46819475 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019212
 protein coding gene Chr14:42944903-42947910 (+)
CAST/EiJ MGP_CASTEiJ_G0020529
 protein coding gene Chr14:42155208-42158215 (+)
CBA/J MGP_CBAJ_G0020972
 protein coding gene Chr14:48272386-48275393 (+)
DBA/2J MGP_DBA2J_G0021096
 protein coding gene Chr14:43500159-43503166 (+)
FVB/NJ MGP_FVBNJ_G0021077
 protein coding gene Chr14:43126815-43129822 (+)
LP/J MGP_LPJ_G0021164
 protein coding gene Chr14:45243557-45246564 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021105
 protein coding gene Chr14:47759084-47762091 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021689
 protein coding gene Chr14:44738900-44741907 (+)
PWK/PhJ MGP_PWKPhJ_G0020279
 protein coding gene Chr14:40405723-40408730 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020104
 protein coding gene Chr14:40914027-40917010 (+)
WSB/EiJ MGP_WSBEiJ_G0020582
 protein coding gene Chr14:44939915-44942922 (+)



Homology
more
  • Human Ortholog
    RNASE10, ribonuclease A family member 10 (inactive)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNASE10, ribonuclease A family member 10 (inactive)
  • Synonyms
    RAH1, RNASE9
  • Links
    NCBI Gene ID: 338879
    neXtProt AC: NX_Q5GAN6
    UniProt: Q5GAN6

  • Chr Location
    14q11.2; chr14:20504233-20513884 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Rnase10
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    13 strains or lines available
Homozygous disruption of this gene leads to decreased bone mineral density, alterations in B cell, T cell and NK cell number, and abnormal circulating glucose, creatinine, chloride and serum albumin levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021872 Ensembl Gene Model | MGI Sequence Detail 3008 C57BL/6J ±  kb
transcript ENSMUST00000022424 Ensembl | MGI Sequence Detail 1629 Not Applicable  
polypeptide ENSMUSP00000022424 Ensembl | MGI Sequence Detail 245 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 36
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:334056 Jun HJ, et al., Male sterility in ROS1 receptor tyrosine kinase conditionally deleted in epididymal epithelial. Biochim Biophys Acta Mol Cell Res. 2022 Dec 16;1870(3):119413
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory