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Ct55 Gene Detail
Summary
  • Symbol
    Ct55
  • Name
    cancer/testis antigen 55
  • Synonyms
    4930502E18Rik, Ct55
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922263
    NCBI Gene: 75013
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:52726622-52740532 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 29.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922263
protein coding gene ChrX:52718510-52740532 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035729
protein coding gene ChrX:48998057-49011665 (+)
A/J MGP_AJ_G0035711
protein coding gene ChrX:48891596-48907001 (+)
AKR/J MGP_AKRJ_G0035632
protein coding gene ChrX:50254179-50270125 (+)
BALB/cJ MGP_BALBcJ_G0035698
protein coding gene ChrX:48366419-48380276 (+)
C3H/HeJ MGP_C3HHeJ_G0035401
protein coding gene ChrX:49277768-49291414 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036227
protein coding gene ChrX:50179660-50193425 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033079
protein coding gene ChrX:46282164-46296128 (+)
CAST/EiJ MGP_CASTEiJ_G0034694
protein coding gene ChrX:36560461-36574802 (+)
CBA/J MGP_CBAJ_G0035375
protein coding gene ChrX:51572428-51587868 (+)
DBA/2J MGP_DBA2J_G0035530
protein coding gene ChrX:48622789-48636190 (+)
FVB/NJ MGP_FVBNJ_G0035479
protein coding gene ChrX:48244075-48257364 (+)
LP/J MGP_LPJ_G0035618
protein coding gene ChrX:49384372-49397770 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035518
protein coding gene ChrX:53111721-53125390 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036245
protein coding gene ChrX:48893149-48906749 (+)
PWK/PhJ MGP_PWKPhJ_G0034392
protein coding gene ChrX:36102159-36116191 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034235
protein coding gene ChrX:37380550-37394954 (+)
WSB/EiJ MGP_WSBEiJ_G0034837
protein coding gene ChrX:48458367-48472012 (+)



Homology
more
  • Human Ortholog
    CT55, cancer/testis antigen 55
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CT55, cancer/testis antigen 55
  • Synonyms
    BJHCC20A, CXorf48, SPGFX7
  • Links
    NCBI Gene ID: 54967
    neXtProt AC: NX_Q8WUE5
    UniProt: Q8WUE5

  • Chr Location
    Xq26.3; chrX:135156536-135171827 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human CT55 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show reduced susceptibility to weight loss, rectal prolapse and visible tumors in an AOM/DSS model of colitis and tumorogenesis. Mice homozygous for a different null allele show a progressive decline in male fertility along with defects in acrosome development, sperm individualization, excess cytoplasm removal and cumulus-oocyte complex penetration capacity, and an impaired autophagic process during spermatogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75013 NCBI Gene Model | MGI Sequence Detail 13911 C57BL/6J ±  kb
    transcript NM_029142 RefSeq | MGI Sequence Detail 1203 Not Specified  
    polypeptide Q14BQ3 UniProt | EBI | MGI Sequence Detail 236 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 2
    References
    more
    • Summaries
      All 24
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:337211 Zhang G, et al., Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice. Cell Death Differ. 2023 Feb;30(2):500-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory