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Tmem168 Gene Detail
Summary
  • Symbol
    Tmem168
  • Name
    transmembrane protein 168
  • Synonyms
    5730526F17Rik, 8430437G11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921794
    NCBI Gene: 101118
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:13580688-13608097 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 5.68 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    153 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921794
 protein coding gene Chr6:13580686-13608099 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030459
 protein coding gene Chr6:10658928-10686207 (-)
A/J MGP_AJ_G0030432
 protein coding gene Chr6:10243146-10270607 (-)
AKR/J MGP_AKRJ_G0030359
 protein coding gene Chr6:10602207-10629544 (-)
BALB/cJ MGP_BALBcJ_G0030441
 protein coding gene Chr6:10236400-10263534 (-)
C3H/HeJ MGP_C3HHeJ_G0030155
 protein coding gene Chr6:10493093-10520890 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030896
 protein coding gene Chr6:11056906-11086143 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028107
 protein coding gene Chr6:9450944-9477058 (-)
CAST/EiJ MGP_CASTEiJ_G0029557
 protein coding gene Chr6:10355753-10384927 (-)
CBA/J MGP_CBAJ_G0030133
 protein coding gene Chr6:11340348-11370284 (-)
DBA/2J MGP_DBA2J_G0030277
 protein coding gene Chr6:10172933-10200893 (-)
FVB/NJ MGP_FVBNJ_G0030231
 protein coding gene Chr6:10081456-10108735 (-)
LP/J MGP_LPJ_G0030364
 protein coding gene Chr6:10613570-10641027 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030267
 protein coding gene Chr6:12114614-12143469 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030926
 protein coding gene Chr6:10489002-10516254 (-)
PWK/PhJ MGP_PWKPhJ_G0029271
 protein coding gene Chr6:9877956-9905322 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029107
 protein coding gene Chr6:10363927-10401182 (-)
WSB/EiJ MGP_WSBEiJ_G0029633
 protein coding gene Chr6:10423583-10452373 (-)



Homology
more
  • Human Ortholog
    TMEM168, transmembrane protein 168
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM168, transmembrane protein 168
  • Links
    NCBI Gene ID: 64418
    neXtProt AC: NX_Q9H0V1
    UniProt: Q9H0V1

  • Chr Location
    7q31.1; chr7:112762377-112790423 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    4
  • cDNA Data
    12
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 101118 NCBI Gene Model | MGI Sequence Detail 27410 C57BL/6J ±  kb
transcript NM_028990 RefSeq | MGI Sequence Detail 4583 C57BL/6  
polypeptide Q91VX9 UniProt | EBI | MGI Sequence Detail 697 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 6
Other
Accession IDs
less
MGI:1889843, MGI:1917921, MGI:2141436
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:303083 Shimizu A, et al., Identification of transmembrane protein 168 mutation in familial Brugada syndrome. FASEB J. 2020 May;34(5):6399-6417
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory