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Cdkal1 Gene Detail
Summary
  • Symbol
    Cdkal1
  • Name
    CDK5 regulatory subunit associated protein 1-like 1
  • Synonyms
    1190005B03Rik, 6620401C13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921765
    NCBI Gene: 68916
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:29375729-30039657 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 12.93 cM, cytoband A3.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3001 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921765
 protein coding gene Chr13:29375729-30039665 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020410
 protein coding gene Chr13:26995848-27692150 (-)
A/J MGP_AJ_G0020365
 protein coding gene Chr13:26362164-27014104 (-)
AKR/J MGP_AKRJ_G0020342
 protein coding gene Chr13:26872973-27567602 (-)
BALB/cJ MGP_BALBcJ_G0020360
 protein coding gene Chr13:26426465-27082732 (-)
C3H/HeJ MGP_C3HHeJ_G0020163
 protein coding gene Chr13:26919363-27603571 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020796
 protein coding gene Chr13:27969399-28640909 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018387
 protein coding gene Chr13:24769389-25430826 (-)
CAST/EiJ MGP_CASTEiJ_G0019680
 protein coding gene Chr13:26559786-27233288 (-)
CBA/J MGP_CBAJ_G0020119
 protein coding gene Chr13:29148775-29871103 (-)
DBA/2J MGP_DBA2J_G0020241
 protein coding gene Chr13:25887995-26546030 (-)
FVB/NJ MGP_FVBNJ_G0020226
 protein coding gene Chr13:25486806-26147679 (-)
LP/J MGP_LPJ_G0020318
 protein coding gene Chr13:27265075-27956757 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020252
 protein coding gene Chr13:29340925-30045828 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020837
 protein coding gene Chr13:26541454-27211013 (-)
PWK/PhJ MGP_PWKPhJ_G0019435
 protein coding gene Chr13:26009000-26680365 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019256
 protein coding gene Chr13:25446619-26125270 (-)
WSB/EiJ MGP_WSBEiJ_G0019742
 protein coding gene Chr13:26804397-27504288 (-)



Homology
more
  • Human Ortholog
    CDKAL1, CDK5 regulatory subunit associated protein 1 like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDKAL1, CDK5 regulatory subunit associated protein 1 like 1
  • Links
    NCBI Gene ID: 54901
    neXtProt AC: NX_Q5VV42
    UniProt: Q5VV42

  • Chr Location
    6p22.3; chr6:20534457-21232404 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cdkal1 mouse models; 4 with human CDKAL1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 5 alleles in 6 genetic backgrounds
    2 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit impaired tRNALys modification. Mice homozygous for a gene trap allele exhibit altered glucose homeostasis and lipid accumulation at early stages when fed a high fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    5
  • cDNA Data
    27
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006191 Ensembl Gene Model | MGI Sequence Detail 663929 C57BL/6J ±  kb
    transcript ENSMUST00000006353 Ensembl | MGI Sequence Detail 2629 Not Applicable  
    polypeptide ENSMUSP00000006353 Ensembl | MGI Sequence Detail 578 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 27
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916166
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:286096 Santos MCFD, et al., Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification. Nat Commun. 2020 Jan 15;11(1):296
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory