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Hsf2bp Gene Detail
Summary
  • Symbol
    Hsf2bp
  • Name
    heat shock transcription factor 2 binding protein
  • Synonyms
    4932437G14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921627
    NCBI Gene: 74377
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:32163743-32253869 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    423 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921627
 protein coding gene Chr17:32163743-32255323 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023496
 protein coding gene Chr17:31755608-31849174 (-)
A/J MGP_AJ_G0023453
 protein coding gene Chr17:30707981-30800696 (-)
AKR/J MGP_AKRJ_G0023419
 protein coding gene Chr17:30981411-31068326 (-)
BALB/cJ MGP_BALBcJ_G0023458
 protein coding gene Chr17:30782090-30890764 (-)
C3H/HeJ MGP_C3HHeJ_G0023220
 protein coding gene Chr17:31354172-31444809 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023901
 protein coding gene Chr17:32858952-32946469 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021375
 protein coding gene Chr17:27825334-27906750 (-)
CAST/EiJ MGP_CASTEiJ_G0022721
 protein coding gene Chr17:31431999-31508119 (-)
CBA/J MGP_CBAJ_G0023195
 protein coding gene Chr17:34257536-34359425 (-)
DBA/2J MGP_DBA2J_G0023325
 protein coding gene Chr17:30093488-30179414 (-)
FVB/NJ MGP_FVBNJ_G0023295
 protein coding gene Chr17:29912610-30001659 (-)
LP/J MGP_LPJ_G0023403
 protein coding gene Chr17:31965447-32058525 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023313
 protein coding gene Chr17:33344614-33433977 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023943
 protein coding gene Chr17:31345675-31430449 (-)
PWK/PhJ MGP_PWKPhJ_G0022470
 protein coding gene Chr17:28970473-29060884 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022289
 protein coding gene Chr17:29329355-29426813 (-)
WSB/EiJ MGP_WSBEiJ_G0022783
 protein coding gene Chr17:31317278-31404775 (-)



Homology
more
  • Human Ortholog
    HSF2BP, heat shock transcription factor 2 binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSF2BP, heat shock transcription factor 2 binding protein
  • Synonyms
    MEILB2, POF19
  • Links
    NCBI Gene ID: 11077
    neXtProt AC: NX_O75031
    UniProt: O75031

  • Chr Location
    21q22.3; chr21:43444972-43659488 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hsf2bp mouse models; 1 with human HSF2BP associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 5 alleles in 5 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects double-stranded DNA break repair, resulting in abnormal meiosis, which in turn leads to male sterility. KO mice are born at lower than expected Mendelian ratio.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    890
  • Tissues
    147
  • cDNA Data
    14
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74377 NCBI Gene Model | MGI Sequence Detail 90127 C57BL/6J ±  kb
    transcript NM_028902 RefSeq | MGI Sequence Detail 2867 C57BL/6  
    polypeptide Q9D4G2 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 14
      Primer pair 3
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 8
      Diseases 3
      Gene Ontology 10
      Phenotypes 30
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:341136 Muza PM, et al., Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture. iScience. 2023 Feb 17;26(2):106073
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory