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Crtc2 Gene Detail
Summary
  • Symbol
    Crtc2
  • Name
    CREB regulated transcription coactivator 2
  • Synonyms
    4632407F12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921593
    NCBI Gene: 74343
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90161475-90171432 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.21 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921593
 protein coding gene Chr3:90161470-90171432 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027459
 protein coding gene Chr3:90550243-90560205 (+)
A/J MGP_AJ_G0027423
 protein coding gene Chr3:87538145-87548107 (+)
AKR/J MGP_AKRJ_G0027388
 protein coding gene Chr3:89685942-89695904 (+)
BALB/cJ MGP_BALBcJ_G0027432
 protein coding gene Chr3:87497712-87507674 (+)
C3H/HeJ MGP_C3HHeJ_G0027174
 protein coding gene Chr3:89853034-89862996 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027878
 protein coding gene Chr3:93956241-93966203 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025231
 protein coding gene Chr3:83034514-83044432 (+)
CAST/EiJ MGP_CASTEiJ_G0026620
 protein coding gene Chr3:90236787-90246747 (+)
CBA/J MGP_CBAJ_G0027149
 protein coding gene Chr3:97193046-97203008 (+)
DBA/2J MGP_DBA2J_G0027286
 protein coding gene Chr3:86907663-86917625 (+)
FVB/NJ MGP_FVBNJ_G0027254
 protein coding gene Chr3:85244659-85254621 (+)
LP/J MGP_LPJ_G0027395
 protein coding gene Chr3:91617975-91627937 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027275
 protein coding gene Chr3:103392631-103402589 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027937
 protein coding gene Chr3:89439192-89449154 (+)
PWK/PhJ MGP_PWKPhJ_G0026354
 protein coding gene Chr3:86795801-86805841 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026174
 protein coding gene Chr3:88611693-88621648 (+)
WSB/EiJ MGP_WSBEiJ_G0026702
 protein coding gene Chr3:89831636-89841594 (+)



Homology
more
  • Human Ortholog
    CRTC2, CREB regulated transcription coactivator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRTC2, CREB regulated transcription coactivator 2
  • Synonyms
    TORC2, TORC-2
  • Links
    NCBI Gene ID: 200186
    neXtProt AC: NX_Q53ET0
    UniProt: Q53ET0

  • Chr Location
    1q21.3; chr1:153947669-153958615 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased circulating corticosterone levels, hepatocyte secretion of glucose in response to glucagon, and glycogen levels in liver and muscle cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    102
  • cDNA Data
    51
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74343 NCBI Gene Model | MGI Sequence Detail 9958 C57BL/6J ±  kb
    transcript NM_028881 RefSeq | MGI Sequence Detail 2603 C57BL/6  
    polypeptide Q3U182 UniProt | EBI | MGI Sequence Detail 692 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005902 CREB-regulated transcription coactivator 2
      (term hierarchy)
    • PDB
      5ZK1, 5ZKO
    • InterPro Domains
      IPR024786 CREB-regulated transcription coactivator
      IPR024785 Transducer of regulated CREB activity, C-terminal
      IPR024784 Transducer of regulated CREB activity, middle domain
      IPR024783 Transducer of regulated CREB activity, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 51
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 15
      Phenotypes 29
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:338967 Han HS, et al., Impaired BCAA catabolism in adipose tissues promotes age-associated metabolic derangement. Nat Aging. 2023 Aug;3(8):982-1000
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory