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Ccdc3 Gene Detail
Summary
  • Symbol
    Ccdc3
  • Name
    coiled-coil domain containing 3
  • Synonyms
    2310045O21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921436
    NCBI Gene: 74186
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:5142587-5235682 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 3.25 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    361 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921436
 protein coding gene Chr2:5142587-5235689 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025321
 protein coding gene Chr2:2241257-2344780 (+)
A/J MGP_AJ_G0025298
 protein coding gene Chr2:2123752-2217478 (+)
AKR/J MGP_AKRJ_G0025266
 protein coding gene Chr2:2175879-2270618 (+)
BALB/cJ MGP_BALBcJ_G0025294
 protein coding gene Chr2:2105124-2200339 (+)
C3H/HeJ MGP_C3HHeJ_G0025054
 protein coding gene Chr2:2162704-2266752 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025736
 protein coding gene Chr2:2262600-2371311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023150
 protein coding gene Chr2:1979357-2068061 (+)
CAST/EiJ MGP_CASTEiJ_G0024517
 protein coding gene Chr2:2186828-2295644 (+)
CBA/J MGP_CBAJ_G0025033
 protein coding gene Chr2:2368476-2479084 (+)
DBA/2J MGP_DBA2J_G0025165
 protein coding gene Chr2:2087724-2181202 (+)
FVB/NJ MGP_FVBNJ_G0025127
 protein coding gene Chr2:2076678-2168924 (+)
LP/J MGP_LPJ_G0025251
 protein coding gene Chr2:2222212-2318414 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025159
 protein coding gene Chr2:2257669-2364802 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025794
 protein coding gene Chr2:2174877-2275883 (+)
PWK/PhJ MGP_PWKPhJ_G0024268
 protein coding gene Chr2:2074311-2171364 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024068
 protein coding gene Chr2:2184839-2285870 (+)
WSB/EiJ MGP_WSBEiJ_G0024587
 protein coding gene Chr2:2188341-2293438 (+)



Homology
more
  • Human Ortholog
    CCDC3, coiled-coil domain containing 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC3, coiled-coil domain containing 3
  • Links
    NCBI Gene ID: 83643
    neXtProt AC: NX_Q9BQI4
    UniProt: Q9BQI4

  • Chr Location
    10p13; chr10:12896625-13099989 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Aging mice homozygous for a null allele are lean and show decreased epididymal and subcutaneous adipose tissue weight and adipocyte size, mild hyperglycemia, increased insulin sensitivity, reduced liver triglyceride levels and steatosis, and fewer inflammatory cells in epididymal fat tissue.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    16
  • cDNA Data
    21
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74186 NCBI Gene Model | MGI Sequence Detail 93096 C57BL/6J ±  kb
    transcript NM_028804 RefSeq | MGI Sequence Detail 2769 C57BL/6  
    polypeptide Q9D6Y1 UniProt | EBI | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 21
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:330630 Kobayashi S, et al., Favine/CCDC3 deficiency accelerated atherosclerosis and thrombus formation is associated with decreased MEF2C-KLF2 pathway. iScience. 2022 Nov 18;25(11):105252
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory