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Acot12 Gene Detail
Summary
  • Symbol
    Acot12
  • Name
    acyl-CoA thioesterase 12
  • Synonyms
    1300004O04Rik, 4930449F15Rik, Cach
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921406
    NCBI Gene: 74156
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:91889635-91934271 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 13, 47.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    418 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921406
protein coding gene Chr13:91889631-91934271 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020808
protein coding gene Chr13:93028663-93079920 (+)
A/J MGP_AJ_G0020762
protein coding gene Chr13:89589779-89637332 (+)
AKR/J MGP_AKRJ_G0020735
protein coding gene Chr13:92309345-92354359 (+)
BALB/cJ MGP_BALBcJ_G0020758
protein coding gene Chr13:90230666-90276682 (+)
C3H/HeJ MGP_C3HHeJ_G0020552
protein coding gene Chr13:91998649-92057228 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021195
protein coding gene Chr13:95888453-95939959 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018763
protein coding gene Chr13:85551543-85590817 (+)
CAST/EiJ MGP_CASTEiJ_G0020071
protein coding gene Chr13:91262766-91321674 (+)
CBA/J MGP_CBAJ_G0020511
protein coding gene Chr13:99683672-99731301 (+)
DBA/2J MGP_DBA2J_G0020636
protein coding gene Chr13:89351752-89395980 (+)
FVB/NJ MGP_FVBNJ_G0020616
protein coding gene Chr13:88168228-88212988 (+)
LP/J MGP_LPJ_G0020709
protein coding gene Chr13:93151741-93199313 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020645
protein coding gene Chr13:100196364-100246050 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021235
protein coding gene Chr13:91717052-91762135 (+)
PWK/PhJ MGP_PWKPhJ_G0019823
protein coding gene Chr13:88104556-88149358 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019647
protein coding gene Chr13:87982059-88028189 (+)
WSB/EiJ MGP_WSBEiJ_G0020128
protein coding gene Chr13:92195963-92242603 (+)



Homology
more
  • Human Ortholog
    ACOT12, acyl-CoA thioesterase 12
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACOT12, acyl-CoA thioesterase 12
  • Synonyms
    Cach, CACH-1, STARD15, THEAL
  • Links
    NCBI Gene ID: 134526
    neXtProt AC: NX_Q8WYK0
    UniProt: Q8WYK0

  • Chr Location
    5q14.1; chr5:81308609-81394179 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit accelerated liver tumor formation in DEN/CCl4-induced and diet-induced hepatocarcinogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74156 NCBI Gene Model | MGI Sequence Detail 44637 C57BL/6J ±  kb
    transcript NM_028790 RefSeq | MGI Sequence Detail 3058 C57BL/6  
    polypeptide Q9DBK0 UniProt | EBI | MGI Sequence Detail 556 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 13

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922149, MGI:2145388
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:342276 Song J, et al., Upregulated FOXM1 stimulates chondrocyte senescence in Acot12(-/-)Nudt7(-/-) double knockout mice. Theranostics. 2023;13(15):5207-5222

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory