About   Help   FAQ
Syvn1 Gene Detail
Summary
  • Symbol
    Syvn1
  • Name
    synovial apoptosis inhibitor 1, synoviolin
  • Synonyms
    1200010C09Rik, Hrd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921376
    NCBI Gene: 74126
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6096606-6103742 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.34 cM, cytoband A
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921376
 protein coding gene Chr19:6096586-6103748 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024737
 protein coding gene Chr19:3074162-3081298 (+)
A/J MGP_AJ_G0024703
 protein coding gene Chr19:2903272-2910420 (+)
AKR/J MGP_AKRJ_G0024676
 protein coding gene Chr19:2993723-3000871 (+)
BALB/cJ MGP_BALBcJ_G0024703
 protein coding gene Chr19:2898516-2905664 (+)
C3H/HeJ MGP_C3HHeJ_G0024471
 protein coding gene Chr19:3012318-3019466 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025150
 protein coding gene Chr19:3133110-3140246 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022583
 protein coding gene Chr19:2832902-2840013 (+)
CAST/EiJ MGP_CASTEiJ_G0023943
 protein coding gene Chr19:3019903-3027062 (+)
CBA/J MGP_CBAJ_G0024443
 protein coding gene Chr19:3283227-3290374 (+)
DBA/2J MGP_DBA2J_G0024570
 protein coding gene Chr19:2890401-2897548 (+)
FVB/NJ MGP_FVBNJ_G0024536
 protein coding gene Chr19:2902215-2909366 (+)
LP/J MGP_LPJ_G0024656
 protein coding gene Chr19:3054013-3061149 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024566
 protein coding gene Chr19:3103341-3110489 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025198
 protein coding gene Chr19:3022528-3029664 (+)
PWK/PhJ MGP_PWKPhJ_G0023689
 protein coding gene Chr19:2922405-2929543 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023494
 protein coding gene Chr19:2981665-2988810 (+)
WSB/EiJ MGP_WSBEiJ_G0024005
 protein coding gene Chr19:3028309-3035463 (+)



Homology
more
  • Human Ortholog
    SYVN1, synoviolin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYVN1, synoviolin 1
  • Synonyms
    DER3, HRD1
  • Links
    NCBI Gene ID: 84447
    neXtProt AC: NX_Q86TM6
    UniProt: Q86TM6

  • Chr Location
    11q13.1; chr11:65121780-65134532 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Haploinsufficiency results in embryonic death due to systemic abnormal apoptosis. Mice are viable when only a single copy is inactivated and they exhibit a resistance to collagen-induced arthritis due to enhanced apoptosis of synovial cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    2
  • cDNA Data
    139
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024807 Ensembl Gene Model | MGI Sequence Detail 7137 C57BL/6J ±  kb
    transcript ENSMUST00000134667 Ensembl | MGI Sequence Detail 3159 Not Applicable  
    polypeptide ENSMUSP00000114960 Ensembl | MGI Sequence Detail 612 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      cDNA 139
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147717, MGI:2147800
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 4
      Gene Ontology 15
      Phenotypes 24
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345648 Lin LL, et al., SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex. Nat Commun. 2024 Feb 16;15(1):1440
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory