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Pi16 Gene Detail
Summary
  • Symbol
    Pi16
  • Name
    peptidase inhibitor 16
  • Synonyms
    1200009H11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921366
    NCBI Gene: 74116
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:29537770-29547876 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.22 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921366
 protein coding gene Chr17:29536654-29549567 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023462
 protein coding gene Chr17:28842903-28854437 (+)
A/J MGP_AJ_G0023420
 protein coding gene Chr17:27854232-27864487 (+)
AKR/J MGP_AKRJ_G0023385
 protein coding gene Chr17:28083398-28095888 (+)
BALB/cJ MGP_BALBcJ_G0023425
 protein coding gene Chr17:28115460-28127781 (+)
C3H/HeJ MGP_C3HHeJ_G0023186
 protein coding gene Chr17:28472807-28483632 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023867
 protein coding gene Chr17:29988007-29998883 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021342
 protein coding gene Chr17:25178210-25187959 (+)
CAST/EiJ MGP_CASTEiJ_G0022687
 protein coding gene Chr17:28447575-28458581 (+)
CBA/J MGP_CBAJ_G0023161
 protein coding gene Chr17:31099049-31109319 (+)
DBA/2J MGP_DBA2J_G0023291
 protein coding gene Chr17:27376918-27387181 (+)
FVB/NJ MGP_FVBNJ_G0023261
 protein coding gene Chr17:27217916-27227650 (+)
LP/J MGP_LPJ_G0023369
 protein coding gene Chr17:29093203-29105373 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023279
 protein coding gene Chr17:30442276-30455330 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023909
 protein coding gene Chr17:28550296-28563534 (+)
PWK/PhJ MGP_PWKPhJ_G0022437
 protein coding gene Chr17:26220830-26230779 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022255
 protein coding gene Chr17:26528006-26538914 (+)
WSB/EiJ MGP_WSBEiJ_G0022749
 protein coding gene Chr17:28503288-28516312 (+)



Homology
more
  • Human Ortholog
    PI16, peptidase inhibitor 16
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PI16, peptidase inhibitor 16
  • Synonyms
    CD364, CRISP9, MSMBBP, PSPBP
  • Links
    NCBI Gene ID: 221476
    neXtProt AC: NX_Q6UXB8
    UniProt: Q6UXB8

  • Chr Location
    6p21.2; chr6:36948263-36964837 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibited numerous immunological abnormalities during tissue-specific FACS analyses including an increased percentage of CD25+ cells in lymph node and B cell compartment differences in bone marrow spleen and lymph node.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    8
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74116 NCBI Gene Model | MGI Sequence Detail 10107 C57BL/6J ±  kb
    transcript NM_023734 RefSeq | MGI Sequence Detail 2245 C57BL/6  
    polypeptide Q9ET66 UniProt | EBI | MGI Sequence Detail 498 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 2
      cDNA 17

      Microarray probesets 4
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:337751 Garrity R, et al., Fibroblast-derived PI16 sustains inflammatory pain via regulation of CD206(+) myeloid cells. Brain Behav Immun. 2023 Jun 12;112:220-234
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory