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Syce1 Gene Detail
Summary
  • Symbol
    Syce1
  • Name
    synaptonemal complex central element protein 1
  • Synonyms
    4933406J07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921325
    NCBI Gene: 74075
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:140357142-140367765 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 85.96 cM, cytoband F5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    82 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921325
 protein coding gene Chr7:140357142-140367767 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033190
 protein coding gene Chr7:145906855-145917480 (-)
A/J MGP_AJ_G0033172
 protein coding gene Chr7:141759270-141769895 (-)
AKR/J MGP_AKRJ_G0033104
 protein coding gene Chr7:145648096-145658721 (-)
BALB/cJ MGP_BALBcJ_G0033173
 protein coding gene Chr7:141486067-141496692 (-)
C3H/HeJ MGP_C3HHeJ_G0032887
 protein coding gene Chr7:145401288-145411913 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033684
 protein coding gene Chr7:151244240-151254865 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030657
 protein coding gene Chr7:142974187-142984862 (-)
CAST/EiJ MGP_CASTEiJ_G0032217
 protein coding gene Chr7:137700004-137710638 (-)
CBA/J MGP_CBAJ_G0032859
 protein coding gene Chr7:156372195-156382812 (-)
DBA/2J MGP_DBA2J_G0033012
 protein coding gene Chr7:139697820-139708445 (-)
FVB/NJ MGP_FVBNJ_G0032964
 protein coding gene Chr7:139608535-139619160 (-)
LP/J MGP_LPJ_G0033106
 protein coding gene Chr7:147403520-147414145 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032997
 protein coding gene Chr7:157043780-157054405 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033704
 protein coding gene Chr7:144630613-144641238 (-)
PWK/PhJ MGP_PWKPhJ_G0031922
 protein coding gene Chr7:132956278-132967014 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031768
 protein coding gene Chr7:131448272-131458924 (-)
WSB/EiJ MGP_WSBEiJ_G0032328
 protein coding gene Chr7:145543603-145554226 (-)



Homology
more
  • Human Ortholog
    SYCE1, synaptonemal complex central element protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYCE1, synaptonemal complex central element protein 1
  • Synonyms
    C10orf94, CT76, POF12, SPGF15
  • Links
    NCBI Gene ID: 93426
    neXtProt AC: NX_Q8N0S2
    UniProt: Q8N0S2

  • Chr Location
    10q26.3; chr10:133553899-133569835 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Syce1 mouse models; 2 with human SYCE1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit small ovaries and small testes, severe defects in gametogenesis, and infertility in both sexes. Meiosis is arrested, homologous chromosomes fail to synapse, and meiotic double-strand breaks are formed but are not efficiently repaired.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    21
  • cDNA Data
    17
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025480 Ensembl Gene Model | MGI Sequence Detail 10624 C57BL/6J ±  kb
    transcript ENSMUST00000026553 Ensembl | MGI Sequence Detail 1460 Not Applicable  
    polypeptide ENSMUSP00000026553 Ensembl | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 17
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory