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Tdrkh Gene Detail
Summary
  • Symbol
    Tdrkh
  • Name
    tudor and KH domain containing protein
  • Synonyms
    2700091C21Rik, Tdrd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919884
    NCBI Gene: 72634
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:94320580-94341975 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.62 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919884
 protein coding gene Chr3:94320551-94342161 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027549
 protein coding gene Chr3:94986627-95004851 (+)
A/J MGP_AJ_G0027508
 protein coding gene Chr3:92096782-92116828 (+)
AKR/J MGP_AKRJ_G0027476
 protein coding gene Chr3:94187231-94210803 (+)
BALB/cJ MGP_BALBcJ_G0027519
 protein coding gene Chr3:91799192-91817421 (+)
C3H/HeJ MGP_C3HHeJ_G0027255
 protein coding gene Chr3:94478073-94505314 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027968
 protein coding gene Chr3:98577271-98595502 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025310
 protein coding gene Chr3:88586984-88608084 (+)
CAST/EiJ MGP_CASTEiJ_G0026703
 protein coding gene Chr3:93828640-93852767 (+)
CBA/J MGP_CBAJ_G0027231
 protein coding gene Chr3:102067922-102091531 (+)
DBA/2J MGP_DBA2J_G0027370
 protein coding gene Chr3:91356409-91383729 (+)
FVB/NJ MGP_FVBNJ_G0027340
 protein coding gene Chr3:89460963-89479182 (+)
LP/J MGP_LPJ_G0027478
 protein coding gene Chr3:96295070-96314229 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027367
 protein coding gene Chr3:108301464-108324258 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028022
 protein coding gene Chr3:93869383-93887592 (+)
PWK/PhJ MGP_PWKPhJ_G0026431
 protein coding gene Chr3:91248695-91271462 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026252
 protein coding gene Chr3:92208986-92227209 (+)
WSB/EiJ MGP_WSBEiJ_G0026786
 protein coding gene Chr3:94217307-94236068 (+)



Homology
more
  • Human Ortholog
    TDRKH, tudor and KH domain containing
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TDRKH, tudor and KH domain containing
  • Synonyms
    TDRD2
  • Links
    NCBI Gene ID: 11022
    neXtProt AC: NX_Q9Y2W6
    UniProt: Q9Y2W6

  • Chr Location
    1q21.3; chr1:151766486-151791416 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility associated with arrested male meiosis, massive double-strand breaks and impaired piRNA biogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    53
  • cDNA Data
    6
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041912 Ensembl Gene Model | MGI Sequence Detail 21396 C57BL/6J ±  kb
    transcript ENSMUST00000166032 Ensembl | MGI Sequence Detail 5692 Not Applicable  
    polypeptide ENSMUSP00000129635 Ensembl | MGI Sequence Detail 560 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000029785 tudor and KH domain-containing protein
      (term hierarchy)
    • PDB
      1WE8
    • InterPro Domains
      IPR004087 K Homology domain
      IPR004088 K Homology domain, type 1
      IPR036612 K Homology domain, type 1 superfamily
      IPR035437 SNase-like, OB-fold superfamily
      IPR047382 Tudor and KH domain-containing protein, first type I K homology domain
      IPR047381 Tudor and KH domain-containing protein, second type I K homology domain
      IPR002999 Tudor domain
      IPR047380 Tudor domain-containing protein 2-like, tudor domain
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:316804 Gainetdinov I, et al., Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability. Mol Cell. 2021 Dec 2;81(23):4826-4842.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory