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Rexo5 Gene Detail
Summary
  • Symbol
    Rexo5
  • Name
    RNA exonuclease 5
  • Synonyms
    2610020H08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919402
    NCBI Gene: 434234
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:119393229-119448166 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 64.21 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919402
 protein coding gene Chr7:119393229-119488130 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032919
 protein coding gene Chr7:123728304-123784203 (+)
A/J MGP_AJ_G0032902
 protein coding gene Chr7:120524716-120578410 (+)
AKR/J MGP_AKRJ_G0032834
 protein coding gene Chr7:123637194-123693983 (+)
BALB/cJ MGP_BALBcJ_G0032907
 protein coding gene Chr7:120255598-120310927 (+)
C3H/HeJ MGP_C3HHeJ_G0032617
 protein coding gene Chr7:123535172-123597222 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033413
 protein coding gene Chr7:128619050-128678997 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030385
 protein coding gene Chr7:121959424-122011091 (+)
CAST/EiJ MGP_CASTEiJ_G0031945
 protein coding gene Chr7:115290309-115349859 (+)
CBA/J MGP_CBAJ_G0032590
 protein coding gene Chr7:132917993-132973850 (+)
DBA/2J MGP_DBA2J_G0032742
 protein coding gene Chr7:118574038-118627656 (+)
FVB/NJ MGP_FVBNJ_G0032695
 protein coding gene Chr7:118413071-118466527 (+)
LP/J MGP_LPJ_G0032836
 protein coding gene Chr7:125181912-125236587 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032727
 protein coding gene Chr7:134380480-134442469 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033433
 protein coding gene Chr7:122609965-122666407 (+)
PWK/PhJ MGP_PWKPhJ_G0031653
 protein coding gene Chr7:111490126-111549298 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031499
 protein coding gene Chr7:109366853-109423269 (+)
WSB/EiJ MGP_WSBEiJ_G0032058
 protein coding gene Chr7:123516978-123577038 (+)



Homology
more
  • Human Ortholog
    REXO5, RNA exonuclease 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    REXO5, RNA exonuclease 5
  • Synonyms
    NEF-sp
  • Links
    NCBI Gene ID: 81691
    neXtProt AC: NX_Q96IC2
    UniProt: Q96IC2

  • Chr Location
    16p12.3; chr16:20806425-20849665 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a knock-out allele exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    22
  • cDNA Data
    22
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030924 Ensembl Gene Model | MGI Sequence Detail 54938 C57BL/6J ±  kb
transcript ENSMUST00000106520 Ensembl | MGI Sequence Detail 2492 Not Applicable  
polypeptide ENSMUSP00000102130 Ensembl | MGI Sequence Detail 759 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • InterPro Domains
    IPR013520 Exonuclease, RNase T/DNA polymerase III
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR012337 Ribonuclease H-like superfamily
    IPR036397 Ribonuclease H superfamily
    IPR035979 RNA-binding domain superfamily
    IPR034922 RNA exonuclease 1-like, exonuclease domain
    IPR047021 RNA exonuclease REXO1/REXO3/REXO4-like
    IPR000504 RNA recognition motif domain
Molecular
Reagents
less
  • All nucleic 23
    cDNA 22
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:243740 Silva S, et al., Characterization of the mammalian RNA exonuclease 5/NEF-sp as a testis-specific nuclear 3' --> 5' exoribonuclease. RNA. 2017 Sep;23(9):1385-1392
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory