Slc39a5 MGI Mouse Gene Detail - MGI:1919336 - solute carrier family 39 (metal ion transporter), member 5

Symbol

Slc39a5
Name

solute carrier family 39 (metal ion transporter), member 5
Synonyms

1810013D05Rik, 2010205A06Rik, Zip5

Feature Type

protein coding gene
IDs

MGI:1919336
NCBI Gene: 72002
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr10:128231800-128237098 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 76.55 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

45 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919336	protein coding gene	Chr10:128231796-128237145 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017863	protein coding gene	Chr10:132129644-132134936 (-)
A/J	MGP_AJ_G0017838	protein coding gene	Chr10:126822318-126827610 (-)
AKR/J	MGP_AKRJ_G0017801	protein coding gene	Chr10:130545780-130551069 (-)
BALB/cJ	MGP_BALBcJ_G0017802	protein coding gene	Chr10:127205309-127210604 (-)
C3H/HeJ	MGP_C3HHeJ_G0017625	protein coding gene	Chr10:130709190-130714506 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018257	protein coding gene	Chr10:136607088-136612378 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015935	protein coding gene	Chr10:120756853-120762157 (-)
CAST/EiJ	MGP_CASTEiJ_G0017186	protein coding gene	Chr10:131419100-131424397 (-)
CBA/J	MGP_CBAJ_G0017595	protein coding gene	Chr10:142153756-142159045 (-)
DBA/2J	MGP_DBA2J_G0017701	protein coding gene	Chr10:125883648-125888938 (-)
FVB/NJ	MGP_FVBNJ_G0017696	protein coding gene	Chr10:124813015-124818317 (-)
LP/J	MGP_LPJ_G0017775	protein coding gene	Chr10:132722242-132727531 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017724	protein coding gene	Chr10:144759292-144764582 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018297	protein coding gene	Chr10:130645803-130651098 (-)
PWK/PhJ	MGP_PWKPhJ_G0016971	protein coding gene	Chr10:126143834-126149123 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016760	protein coding gene	Chr10:129740251-129745446 (-)
WSB/EiJ	MGP_WSBEiJ_G0017245	protein coding gene	Chr10:130861634-130866923 (-)

Human Ortholog

SLC39A5, solute carrier family 39 member 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC39A5, solute carrier family 39 member 5
Synonyms

LZT-Hs7, MYP24, ZIP5
Links

HGNC:20502

NCBI Gene ID: 283375

neXtProt AC: NX_Q6ZMH5

UniProt: Q6ZMH5
Chr Location

12q13.3; chr12:56230049-56237846 (+) GRCh38

MGI Vertebrate Homology

Slc39a5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC39A5
Gene Tree

Slc39a5

Diseases

1 with human SLC39A5 associations

				Human Disease	Mouse Models
				myopia IDs myopia DOID:11830 ICD10CM:H52.1 ICD9CM:367.1 MESH:D009216 NCI:C102533 OMIM:160700 OMIM:255500 OMIM:300613 OMIM:310460 OMIM:603221 OMIM:608367 OMIM:608474 OMIM:608908 OMIM:609256 OMIM:609257 OMIM:609258 OMIM:609259 OMIM:609994 OMIM:609995 OMIM:610320 OMIM:612554 OMIM:612717 OMIM:613959 OMIM:613969 OMIM:614166 OMIM:614167 OMIM:615420 OMIM:615431 OMIM:615946 UMLS_CUI:C0027092

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 3 alleles in 4 genetic backgrounds
1 images
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Targeted

8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit altered zinc homeostasis and increased susceptibility to zinc-induced pancretitis.

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All GO Annotations

19
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

770
Tissues

43
cDNA Data

25
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc39a5

ZFIN slc39a5

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All Sequences

53
RefSeq

13
UniProt

3
CCDS

CCDS24275.1

Ensembl

ENSMUSG00000039878 (Evidence)
NCBI Gene

72002

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039878	Ensembl Gene Model \| MGI Sequence Detail	5299	C57BL/6J	± kb
transcript	ENSMUST00000042666	Ensembl \| MGI Sequence Detail	1947	Not Applicable
polypeptide	ENSMUSP00000037753	Ensembl \| MGI Sequence Detail	535	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015132 zinc transporter ZIP5

(term hierarchy)
InterPro Domains

IPR003689 Zinc/iron permease

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All nucleic 29

cDNA 26

Primer pair 2

Other 1

Microarray probesets 3

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MGI:1919252

Summaries

All 48

Developmental Gene Expression 8

Gene Ontology 9

Phenotypes 12
Earliest

J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
Latest

J:279170 Wang X, et al., The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic beta-cells via Sirt1- and Pgc-1alpha-mediated regulation of Glut2. Protein Cell. 2019 Jun;10(6):436-449

TSS for Slc39a5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99866	Chr10:128237727-128237749 (-)	-640 bp
Tssr99865	Chr10:128237700-128237722 (-)	-613 bp
Tssr99864	Chr10:128237108-128237121 (-)	-17 bp
Tssr99863	Chr10:128237087-128237103 (-)	3 bp
Tssr99862	Chr10:128237061-128237083 (-)	26 bp
Tssr99861	Chr10:128236366-128236406 (-)	712 bp
Tssr99860	Chr10:128236317-128236342 (-)	768 bp
Tssr99859	Chr10:128236163-128236177 (-)	928 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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