About   Help   FAQ
Cyb5r1 Gene Detail
Summary
  • Symbol
    Cyb5r1
  • Name
    cytochrome b5 reductase 1
  • Synonyms
    1500005G05Rik, B5R.1, Nqo3a2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919267
    NCBI Gene: 72017
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:134333519-134339476 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 58.21 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919267
 protein coding gene Chr1:134333297-134339478 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016506
 protein coding gene Chr1:138064057-138070199 (+)
A/J MGP_AJ_G0016489
 protein coding gene Chr1:132863685-132869824 (+)
AKR/J MGP_AKRJ_G0016454
 protein coding gene Chr1:136824920-136836569 (+)
BALB/cJ MGP_BALBcJ_G0016449
 protein coding gene Chr1:133198862-133205005 (+)
C3H/HeJ MGP_C3HHeJ_G0016275
 protein coding gene Chr1:136928947-136935074 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016910
 protein coding gene Chr1:143097833-143104014 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014621
 protein coding gene Chr1:126001201-126007360 (+)
CAST/EiJ MGP_CASTEiJ_G0015855
 protein coding gene Chr1:135983728-135989974 (+)
CBA/J MGP_CBAJ_G0016248
 protein coding gene Chr1:148054863-148060999 (+)
DBA/2J MGP_DBA2J_G0016354
 protein coding gene Chr1:131879404-131885500 (+)
FVB/NJ MGP_FVBNJ_G0016353
 protein coding gene Chr1:130504518-130510614 (+)
LP/J MGP_LPJ_G0016425
 protein coding gene Chr1:139342587-139348731 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016378
 protein coding gene Chr1:153744541-153750633 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016946
 protein coding gene Chr1:136561785-136567923 (+)
PWK/PhJ MGP_PWKPhJ_G0015641
 protein coding gene Chr1:130902715-130908922 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015428
 protein coding gene Chr1:135535989-135544305 (+)
WSB/EiJ MGP_WSBEiJ_G0015918
 protein coding gene Chr1:136594280-136600434 (+)



Homology
more
  • Human Ortholog
    CYB5R1, cytochrome b5 reductase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYB5R1, cytochrome b5 reductase 1
  • Synonyms
    B5R1, B5R.1, B5R2, humb5R2, NQO3A2
  • Links
    NCBI Gene ID: 51706
    neXtProt AC: NX_Q9UHQ9
    UniProt: Q9UHQ9

  • Chr Location
    1q32.1; chr1:202961873-202967275 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout mice die before birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    9
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 72017 NCBI Gene Model | MGI Sequence Detail 5958 C57BL/6J ±  kb
transcript NR_149307 RefSeq | MGI Sequence Detail 2422 C57BL/6  
polypeptide Q9DB73 UniProt | EBI | MGI Sequence Detail 305 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006080 NADH-cytochrome b5 reductase 1
    (term hierarchy)
  • EC
    1.6.2.2
  • InterPro Domains
    IPR017927 FAD-binding domain, ferredoxin reductase-type
    IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
    IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
    IPR008333 Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain
    IPR001834 NADH:cytochrome b5 reductase-like
    IPR001433 Oxidoreductase FAD/NAD(P)-binding
    IPR017938 Riboflavin synthase-like beta-barrel
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 4
Other
Accession IDs
less
MGI:2138690
References
more
  • Summaries
    All 44
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:344225 Faber JE, et al., Large differences in collateral blood vessel abundance among individuals arise from multiple genetic variants. J Cereb Blood Flow Metab. 2023 Nov;43(11):1983-2004
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory