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Tmem79 Gene Detail
Summary
  • Symbol
    Tmem79
  • Name
    transmembrane protein 79
  • Synonyms
    2310042N02Rik, 2310074C17Rik, ma, Matt, mattrin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919163
    NCBI Gene: 71913
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:88236351-88241761 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.80 cM, cytoband F1
  • Mapping Data
    41 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919163
 protein coding gene Chr3:88235962-88243455 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027390
 protein coding gene Chr3:88481378-88488767 (-)
A/J MGP_AJ_G0027354
 protein coding gene Chr3:85485586-85492959 (-)
AKR/J MGP_AKRJ_G0027320
 protein coding gene Chr3:87588372-87595653 (-)
BALB/cJ MGP_BALBcJ_G0027363
 protein coding gene Chr3:85574820-85582420 (-)
C3H/HeJ MGP_C3HHeJ_G0027106
 protein coding gene Chr3:87865938-87873882 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027809
 protein coding gene Chr3:91739085-91746436 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025162
 protein coding gene Chr3:81103250-81111138 (-)
CAST/EiJ MGP_CASTEiJ_G0026552
 protein coding gene Chr3:88077509-88084824 (-)
CBA/J MGP_CBAJ_G0027081
 protein coding gene Chr3:94864648-94872065 (-)
DBA/2J MGP_DBA2J_G0027217
 protein coding gene Chr3:84972756-84981660 (-)
FVB/NJ MGP_FVBNJ_G0027186
 protein coding gene Chr3:83241946-83251209 (-)
LP/J MGP_LPJ_G0027325
 protein coding gene Chr3:89474669-89482622 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027205
 protein coding gene Chr3:101094503-101101674 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027867
 protein coding gene Chr3:87341987-87350588 (-)
PWK/PhJ MGP_PWKPhJ_G0026285
 protein coding gene Chr3:84771047-84779328 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026103
 protein coding gene Chr3:86527491-86540771 (-)
WSB/EiJ MGP_WSBEiJ_G0026632
 protein coding gene Chr3:87698164-87705490 (-)



Homology
more
  • Human Ortholog
    TMEM79, transmembrane protein 79
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM79, transmembrane protein 79
  • Synonyms
    MATT
  • Links
    NCBI Gene ID: 84283
    neXtProt AC: NX_Q9BSE2
    UniProt: Q9BSE2

  • Chr Location
    1q22; chr1:156282932-156293185 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tmem79 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 3 alleles in 6 genetic backgrounds
    19 phenotypes from multigenic genotypes
    3 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation exhibit abnormal coat/hair pigmentation, abnormal zigzag hair morphology, and a more sparse and shiny coat than wild-type controls. Some adults display a mild irritation around the eyes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    12
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71913 NCBI Gene Model | MGI Sequence Detail 5411 C57BL/6J ±  kb
    transcript NM_001419031 RefSeq | MGI Sequence Detail 2164 C57BL/6  
    polypeptide Q9D709 UniProt | EBI | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12093, MGI:1919175, MGI:96906
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 2
      Diseases 3
      Gene Ontology 5
      Phenotypes 34
    • Earliest
      J:12995 Jarrett A, et al., The keratin defect and hair-cycle of a new mutant (matted) in the house-mouse. J Embryol Exp Morphol. 1957;5(1):103-110
    • Latest
      J:327617 Morimoto A, et al., Microbiota-Independent Spontaneous Dermatitis Associated with Increased Sebaceous Lipid Production in Tmem79-Deficient Mice. J Invest Dermatol. 2022 Jun 23;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory