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Zbtb43 Gene Detail
Summary
  • Symbol
    Zbtb43
  • Name
    zinc finger and BTB domain containing 43
  • Synonyms
    1700010E06Rik, mKIAA0414, Zfp297b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919084
    NCBI Gene: 71834
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:33340299-33358571 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.46 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919084
 protein coding gene Chr2:33340299-33358592 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025634
 protein coding gene Chr2:31973647-31993047 (-)
A/J MGP_AJ_G0025611
 protein coding gene Chr2:30618684-30636845 (-)
AKR/J MGP_AKRJ_G0025581
 protein coding gene Chr2:31710089-31730216 (-)
BALB/cJ MGP_BALBcJ_G0025608
 protein coding gene Chr2:30736081-30754327 (-)
C3H/HeJ MGP_C3HHeJ_G0025368
 protein coding gene Chr2:31593251-31612235 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026052
 protein coding gene Chr2:32922626-32940768 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023461
 protein coding gene Chr2:29348455-29367809 (-)
CAST/EiJ MGP_CASTEiJ_G0024830
 protein coding gene Chr2:31565280-31585645 (-)
CBA/J MGP_CBAJ_G0025346
 protein coding gene Chr2:34195453-34226014 (-)
DBA/2J MGP_DBA2J_G0025479
 protein coding gene Chr2:30383881-30402753 (-)
FVB/NJ MGP_FVBNJ_G0025441
 protein coding gene Chr2:30276829-30295088 (-)
LP/J MGP_LPJ_G0025565
 protein coding gene Chr2:31874476-31893872 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025472
 protein coding gene Chr2:33769639-33793119 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026110
 protein coding gene Chr2:31591851-31611118 (-)
PWK/PhJ MGP_PWKPhJ_G0024578
 protein coding gene Chr2:30300467-30319391 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024378
 protein coding gene Chr2:31766792-31785381 (-)
WSB/EiJ MGP_WSBEiJ_G0024899
 protein coding gene Chr2:31771813-31790831 (-)



Homology
more
  • Human Ortholog
    ZBTB43, zinc finger and BTB domain containing 43
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZBTB43, zinc finger and BTB domain containing 43
  • Synonyms
    ZBTB22B, ZNF297B, ZNF-X
  • Links
    NCBI Gene ID: 23099
    neXtProt AC: NX_O43298
    UniProt: O43298

  • Chr Location
    9q33.3; chr9:126804072-126838210 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    106
  • cDNA Data
    64
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026788 Ensembl Gene Model | MGI Sequence Detail 18273 C57BL/6J ±  kb
    transcript ENSMUST00000113156 Ensembl | MGI Sequence Detail 1828 Not Applicable  
    polypeptide ENSMUSP00000108781 Ensembl | MGI Sequence Detail 504 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 64
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:330622 Meng Y, et al., Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome. Nat Cell Biol. 2022 Jul;24(7):1141-1153
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory