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Prss55 Gene Detail
Summary
  • Symbol
    Prss55
  • Name
    serine protease 55
  • Synonyms
    4933401F05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918287
    NCBI Gene: 71037
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:64312887-64327611 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918287
 protein coding gene Chr14:64312884-64338445 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021469
 protein coding gene Chr14:58640081-58654740 (-)
A/J MGP_AJ_G0021428
 protein coding gene Chr14:57289624-57304518 (-)
AKR/J MGP_AKRJ_G0021404
 protein coding gene Chr14:59316708-59331365 (-)
BALB/cJ MGP_BALBcJ_G0021434
 protein coding gene Chr14:57247359-57262032 (-)
C3H/HeJ MGP_C3HHeJ_G0021211
 protein coding gene Chr14:58943389-58958047 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021873
 protein coding gene Chr14:61378776-61393422 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019413
 protein coding gene Chr14:55225035-55239402 (-)
CAST/EiJ MGP_CASTEiJ_G0020728
 protein coding gene Chr14:55400614-55416733 (-)
CBA/J MGP_CBAJ_G0021178
 protein coding gene Chr14:63236793-63253460 (-)
DBA/2J MGP_DBA2J_G0021301
 protein coding gene Chr14:56964891-56979553 (-)
FVB/NJ MGP_FVBNJ_G0021280
 protein coding gene Chr14:56352797-56368117 (-)
LP/J MGP_LPJ_G0021376
 protein coding gene Chr14:59673724-59688393 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021309
 protein coding gene Chr14:62413289-62430438 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021896
 protein coding gene Chr14:58479862-58494526 (-)
PWK/PhJ MGP_PWKPhJ_G0020472
 protein coding gene Chr14:53640114-53655047 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020305
 protein coding gene Chr14:54441857-54456479 (-)
WSB/EiJ MGP_WSBEiJ_G0020781
 protein coding gene Chr14:58794760-58809414 (-)



Homology
more
  • Human Ortholog
    PRSS55, serine protease 55
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRSS55, serine protease 55
  • Synonyms
    CT153, TSP1, T-SP1, UNQ9391
  • Links
    NCBI Gene ID: 203074
    neXtProt AC: NX_Q6UWB4
    UniProt: Q6UWB4

  • Chr Location
    8p23.1; chr8:10525532-10554166 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 5 alleles in 5 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Different knockout strategies result in inconsistent male reproduction phenotypes ranging from normal spermatogenesis and fertility to severe subfertility with astheno/teratozoospermia and low sperm ATP content to infertility with impaired sperm migration and sperm-egg recognition/binding defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034623 Ensembl Gene Model | MGI Sequence Detail 14725 C57BL/6J ±  kb
    transcript ENSMUST00000089338 Ensembl | MGI Sequence Detail 1032 Not Applicable  
    polypeptide ENSMUSP00000086752 Ensembl | MGI Sequence Detail 321 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:307639 Zhu F, et al., PRSS55 plays an important role in the structural differentiation and energy metabolism of sperm and is required for male fertility in mice. J Cell Mol Med. 2021 Feb;25(4):2040-2051
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory