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Fbln7 Gene Detail
Summary
  • Symbol
    Fbln7
  • Name
    fibulin 7
  • Synonyms
    1600015H20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917620
    NCBI Gene: 70370
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:128705791-128738954 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 62.63 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    468 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917620
protein coding gene Chr2:128704901-128738954 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026477
protein coding gene Chr2:132230925-132264814 (+)
A/J MGP_AJ_G0026441
protein coding gene Chr2:126869283-126903926 (+)
AKR/J MGP_AKRJ_G0026416
protein coding gene Chr2:130465879-130501086 (+)
BALB/cJ MGP_BALBcJ_G0026453
protein coding gene Chr2:127130022-127165459 (+)
C3H/HeJ MGP_C3HHeJ_G0026196
protein coding gene Chr2:130980980-131016134 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026898
protein coding gene Chr2:136362888-136398403 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024275
protein coding gene Chr2:121695073-121728877 (+)
CAST/EiJ MGP_CASTEiJ_G0025657
protein coding gene Chr2:131228526-131264449 (+)
CBA/J MGP_CBAJ_G0026176
protein coding gene Chr2:141398879-141436084 (+)
DBA/2J MGP_DBA2J_G0026310
protein coding gene Chr2:126255511-126289309 (+)
FVB/NJ MGP_FVBNJ_G0026274
protein coding gene Chr2:124904368-124938150 (+)
LP/J MGP_LPJ_G0026415
protein coding gene Chr2:132452070-132491198 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026294
protein coding gene Chr2:145327466-145364228 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026953
protein coding gene Chr2:130510658-130545309 (+)
PWK/PhJ MGP_PWKPhJ_G0025393
protein coding gene Chr2:125831827-125866212 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025195
protein coding gene Chr2:129616582-129650686 (+)
WSB/EiJ MGP_WSBEiJ_G0025731
protein coding gene Chr2:131418391-131453061 (+)



Homology
more
  • Human Ortholog
    FBLN7, fibulin 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBLN7, fibulin 7
  • Synonyms
    TM14
  • Links
    NCBI Gene ID: 129804
    neXtProt AC: NX_Q53RD9
    UniProt: Q53RD9

  • Chr Location
    2q13-q14.1; chr2:112138385-112244708 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are protected from renal tubular calcification and fibrosis induced by high phosphate diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70370 NCBI Gene Model | MGI Sequence Detail 33164 C57BL/6J ±  kb
    transcript NM_024237 RefSeq | MGI Sequence Detail 2922 C57BL/6  
    polypeptide Q501P1 UniProt | EBI | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 35

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138974
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:271278 Tsunezumi J, et al., Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice. Matrix Biol. 2018 Dec;74:5-20

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/05/2024
    MGI 6.23
    The Jackson Laboratory