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Exosc8 Gene Detail
Summary
  • Symbol
    Exosc8
  • Name
    exosome component 8
  • Synonyms
    2310032N20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916889
    NCBI Gene: 69639
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:54636099-54642469 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 25.60 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916889
 protein coding gene Chr3:54636099-54642814 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027214
 protein coding gene Chr3:53428933-53437128 (-)
A/J MGP_AJ_G0027174
 protein coding gene Chr3:51784576-51791291 (-)
AKR/J MGP_AKRJ_G0027144
 protein coding gene Chr3:52843345-52850072 (-)
BALB/cJ MGP_BALBcJ_G0027187
 protein coding gene Chr3:51635992-51642705 (-)
C3H/HeJ MGP_C3HHeJ_G0026930
 protein coding gene Chr3:53055617-53062340 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027633
 protein coding gene Chr3:55465007-55471740 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024992
 protein coding gene Chr3:48305939-48312596 (-)
CAST/EiJ MGP_CASTEiJ_G0026382
 protein coding gene Chr3:53192450-53199180 (-)
CBA/J MGP_CBAJ_G0026906
 protein coding gene Chr3:57234887-57241604 (-)
DBA/2J MGP_DBA2J_G0027040
 protein coding gene Chr3:51344389-51351109 (-)
FVB/NJ MGP_FVBNJ_G0027008
 protein coding gene Chr3:50315754-50322469 (-)
LP/J MGP_LPJ_G0027152
 protein coding gene Chr3:54132491-54139219 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027026
 protein coding gene Chr3:61341979-61349536 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027691
 protein coding gene Chr3:52762164-52768879 (-)
PWK/PhJ MGP_PWKPhJ_G0026114
 protein coding gene Chr3:51018818-51025568 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025927
 protein coding gene Chr3:52521046-52527624 (-)
WSB/EiJ MGP_WSBEiJ_G0026456
 protein coding gene Chr3:52892095-52898821 (-)



Homology
more
  • Human Ortholog
    EXOSC8, exosome component 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EXOSC8, exosome component 8
  • Synonyms
    bA421P11.3, CIP3, EAP2, OIP2, p9, PCH1C, RRP43, Rrp43p
  • Links
    NCBI Gene ID: 11340
    neXtProt AC: NX_Q96B26
    UniProt: Q96B26

  • Chr Location
    13q13.3; chr13:36998816-37025881 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EXOSC8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    56
  • cDNA Data
    11
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69639 NCBI Gene Model | MGI Sequence Detail 6371 C57BL/6J ±  kb
transcript NM_001163570 RefSeq | MGI Sequence Detail 967 C57BL/6  
polypeptide Q9D753 UniProt | EBI | MGI Sequence Detail 276 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000007265 exosome complex component RRP43
    (term hierarchy)
  • InterPro Domains
    IPR036345 Exoribonuclease, PH domain 2 superfamily
    IPR001247 Exoribonuclease, phosphorolytic domain 1
    IPR015847 Exoribonuclease, phosphorolytic domain 2
    IPR033196 Exosome complex component Rrp43
    IPR027408 PNPase/RNase PH domain superfamily
    IPR020568 Ribosomal protein uS5 domain 2-type superfamily
Molecular
Reagents
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  • All nucleic 14
    cDNA 11
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 48
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 7
    Phenotypes 19
  • Earliest
    J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
  • Latest
    J:343201 Srinivasan S, et al., Exosome complex components 1 and 2 are vital for early mammalian development. Gene Expr Patterns. 2023 Nov 7;51:119346
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory