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Mtfmt Gene Detail
Summary
  • Symbol
    Mtfmt
  • Name
    mitochondrial methionyl-tRNA formyltransferase
  • Synonyms
    2310020P08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916856
    NCBI Gene: 69606
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:65343064-65360336 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 35.31 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916856
 protein coding gene Chr9:65343064-65360336 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034959
 protein coding gene Chr9:65169180-65188416 (+)
A/J MGP_AJ_G0034939
 protein coding gene Chr9:62972535-62990648 (+)
AKR/J MGP_AKRJ_G0034869
 protein coding gene Chr9:64465306-64482580 (+)
BALB/cJ MGP_BALBcJ_G0034932
 protein coding gene Chr9:62696104-62713565 (+)
C3H/HeJ MGP_C3HHeJ_G0034642
 protein coding gene Chr9:64993228-65011028 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035451
 protein coding gene Chr9:66951228-66970564 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032362
 protein coding gene Chr9:62621072-62639731 (+)
CAST/EiJ MGP_CASTEiJ_G0033963
 protein coding gene Chr9:65176996-65194087 (+)
CBA/J MGP_CBAJ_G0034613
 protein coding gene Chr9:69294300-69314457 (+)
DBA/2J MGP_DBA2J_G0034772
 protein coding gene Chr9:62742728-62760278 (+)
FVB/NJ MGP_FVBNJ_G0034714
 protein coding gene Chr9:62067094-62084856 (+)
LP/J MGP_LPJ_G0034855
 protein coding gene Chr9:65448229-65465301 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034756
 protein coding gene Chr9:70508344-70530862 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035473
 protein coding gene Chr9:64563015-64581279 (+)
PWK/PhJ MGP_PWKPhJ_G0033667
 protein coding gene Chr9:62947334-62965586 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033501
 protein coding gene Chr9:64847358-64867943 (+)
WSB/EiJ MGP_WSBEiJ_G0034076
 protein coding gene Chr9:64468671-64485891 (+)



Homology
more
  • Human Ortholog
    MTFMT, mitochondrial methionyl-tRNA formyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTFMT, mitochondrial methionyl-tRNA formyltransferase
  • Synonyms
    COXPD15, FMT1, MC1DN27
  • Links
    NCBI Gene ID: 123263
    neXtProt AC: NX_Q96DP5
    UniProt: Q96DP5

  • Chr Location
    15q22.31; chr15:65001512-65029639 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human MTFMT associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    2
  • Targeted
    3
  • Genomic Mutations
    1 involving Mtfmt
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    18 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    31
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69606 NCBI Gene Model | MGI Sequence Detail 17273 C57BL/6J ±  kb
transcript NM_027134 RefSeq | MGI Sequence Detail 2042 C57BL/6  
polypeptide Q9D799 UniProt | EBI | MGI Sequence Detail 386 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 31

    Microarray probesets 4
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:334467 Sun X, et al., Mitochondrial Methionyl-tRNA Formyltransferase Deficiency Alleviates Metaflammation by Modulating Mitochondrial Activity in Mice. Int J Mol Sci. 2023 Mar 22;24(6)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory