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Dab2ip Gene Detail
Summary
  • Symbol
    Dab2ip
  • Name
    disabled 2 interacting protein
  • Synonyms
    2310011D08Rik, AIP1, mKIAA1743
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916851
    NCBI Gene: 69601
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:35448285-35621006 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 23.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    605 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916851
protein coding gene Chr2:35448278-35621006 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025656
protein coding gene Chr2:34204602-34388290 (+)
A/J MGP_AJ_G0025633
protein coding gene Chr2:32753922-32927920 (+)
AKR/J MGP_AKRJ_G0025603
protein coding gene Chr2:33905031-34079750 (+)
BALB/cJ MGP_BALBcJ_G0025630
protein coding gene Chr2:32867224-33041938 (+)
C3H/HeJ MGP_C3HHeJ_G0025390
protein coding gene Chr2:33804496-33981495 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026074
protein coding gene Chr2:35203329-35380163 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023483
protein coding gene Chr2:31443640-31619300 (+)
CAST/EiJ MGP_CASTEiJ_G0024852
protein coding gene Chr2:33805716-34000091 (+)
CBA/J MGP_CBAJ_G0025368
protein coding gene Chr2:36541153-36734891 (+)
DBA/2J MGP_DBA2J_G0025501
protein coding gene Chr2:32524694-32698962 (+)
FVB/NJ MGP_FVBNJ_G0025463
protein coding gene Chr2:32431217-32607116 (+)
LP/J MGP_LPJ_G0025587
protein coding gene Chr2:34127206-34308542 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025494
protein coding gene Chr2:36040898-36223088 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026132
protein coding gene Chr2:33796870-33977202 (+)
PWK/PhJ MGP_PWKPhJ_G0024600
protein coding gene Chr2:32447722-32638641 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024400
protein coding gene Chr2:33982707-34167317 (+)
WSB/EiJ MGP_WSBEiJ_G0024921
protein coding gene Chr2:34001073-34183406 (+)



Homology
more
  • Human Ortholog
    DAB2IP, DAB2 interacting protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DAB2IP, DAB2 interacting protein
  • Synonyms
    AF9Q34, AIP1, AIP-1, DIP1/2
  • Links
    NCBI Gene ID: 153090
    neXtProt AC: NX_Q5VWQ8
    UniProt: Q5VWQ8

  • Chr Location
    9q33.2; chr9:121567057-121785530 (+)  GRCh38

Human Diseases
more
  • Diseases
    8 with human DAB2IP associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired IRE1-mediated endoplasmic reticulum (ER) stress-induced responses. Mice homozygous for a gene trap allele exhibit delayed Purkinje cell dendritogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69601 NCBI Gene Model | MGI Sequence Detail 172722 C57BL/6J ±  kb
transcript NM_001290641 RefSeq | MGI Sequence Detail 6673 C57BL/6  
polypeptide Q3UHC7 UniProt | EBI | MGI Sequence Detail 1189 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 157
    Genomic 2
    cDNA 155

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138979
References
more
  • Summaries
    All 47
    Developmental Gene Expression 6
    Gene Ontology 12
    Phenotypes 18
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory