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Selenot Gene Detail
Summary
  • Symbol
    Selenot
  • Name
    selenoprotein T
  • Synonyms
    2810407C02Rik, 5730408P04Rik, Selt, SelT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916477
    NCBI Gene: 69227
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:58484057-58500554 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 28.61 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916477
 protein coding gene Chr3:58484057-58500965 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027237
 protein coding gene Chr3:57421949-57439392 (+)
A/J MGP_AJ_G0027197
 protein coding gene Chr3:55634264-55649226 (+)
AKR/J MGP_AKRJ_G0027167
 protein coding gene Chr3:56778094-56797526 (+)
BALB/cJ MGP_BALBcJ_G0027210
 protein coding gene Chr3:55445491-55461881 (+)
C3H/HeJ MGP_C3HHeJ_G0026953
 protein coding gene Chr3:56998782-57015746 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027656
 protein coding gene Chr3:59534045-59551684 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025010
 protein coding gene Chr3:51984957-52001645 (+)
CAST/EiJ MGP_CASTEiJ_G0026405
 protein coding gene Chr3:57163154-57182675 (+)
CBA/J MGP_CBAJ_G0026929
 protein coding gene Chr3:61508395-61528312 (+)
DBA/2J MGP_DBA2J_G0027063
 protein coding gene Chr3:55129410-55146335 (+)
FVB/NJ MGP_FVBNJ_G0027031
 protein coding gene Chr3:54101236-54116917 (+)
LP/J MGP_LPJ_G0027175
 protein coding gene Chr3:58174433-58190934 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027049
 protein coding gene Chr3:65644700-65655392 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027714
 protein coding gene Chr3:56735075-56751598 (+)
PWK/PhJ MGP_PWKPhJ_G0026137
 protein coding gene Chr3:54781338-54798529 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025950
 protein coding gene Chr3:56410242-56428739 (+)
WSB/EiJ MGP_WSBEiJ_G0026479
 protein coding gene Chr3:56814521-56832893 (+)



Homology
more
  • Human Ortholog
    SELENOT, selenoprotein T
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SELENOT, selenoprotein T
  • Synonyms
    SELT
  • Links
    NCBI Gene ID: 51714
    neXtProt AC: NX_P62341
    UniProt: P62341

  • Chr Location
    3q25.1; chr3:150602875-150630436 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in beta cells exhibit impaired glucose tolerance, increased circulating glucose levels, decreased circulating insulin levels, decreased insulin secretion and an increase in smaller islets.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    13
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000075700 Ensembl Gene Model | MGI Sequence Detail 16498 C57BL/6J ±  kb
    transcript ENSMUST00000107924 Ensembl | MGI Sequence Detail 3157 Not Applicable  
    polypeptide ENSMUSP00000103557 Ensembl | MGI Sequence Detail 195 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1917762
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:58830 Kryukov GV, et al., New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements. J Biol Chem. 1999 Nov 26;274(48):33888-97
    • Latest
      J:311512 Li K, et al., Hepatic Proteomic Analysis of Selenoprotein T Knockout Mice by TMT: Implications for the Role of Selenoprotein T in Glucose and Lipid Metabolism. Int J Mol Sci. 2021 Aug 7;22(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory