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Fcmr Gene Detail
Summary
  • Symbol
    Fcmr
  • Name
    Fc fragment of IgM receptor
  • Synonyms
    1810037B05Rik, Faim3, FcmuR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916419
    NCBI Gene: 69169
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:130793514-130808528 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 56.89 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916419
 protein coding gene Chr1:130793406-130808528 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016443
 protein coding gene Chr1:134270063-134286463 (+)
A/J MGP_AJ_G0016426
 protein coding gene Chr1:129300274-129315277 (+)
AKR/J MGP_AKRJ_G0016391
 protein coding gene Chr1:133104678-133121861 (+)
BALB/cJ MGP_BALBcJ_G0016386
 protein coding gene Chr1:129631440-129646766 (+)
C3H/HeJ MGP_C3HHeJ_G0016212
 protein coding gene Chr1:133248167-133263117 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016847
 protein coding gene Chr1:139267276-139282244 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014561
 protein coding gene Chr1:122444873-122460118 (+)
CAST/EiJ MGP_CASTEiJ_G0015792
 protein coding gene Chr1:132239422-132255364 (+)
CBA/J MGP_CBAJ_G0016184
 protein coding gene Chr1:144069250-144084249 (+)
DBA/2J MGP_DBA2J_G0016291
 protein coding gene Chr1:128262684-128277677 (+)
FVB/NJ MGP_FVBNJ_G0016290
 protein coding gene Chr1:126905561-126922232 (+)
LP/J MGP_LPJ_G0016362
 protein coding gene Chr1:135579417-135595674 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016315
 protein coding gene Chr1:149830606-149847571 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016883
 protein coding gene Chr1:132866911-132883050 (+)
PWK/PhJ MGP_PWKPhJ_G0015578
 protein coding gene Chr1:127236062-127251099 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015365
 protein coding gene Chr1:131805670-131823957 (+)
WSB/EiJ MGP_WSBEiJ_G0015854
 protein coding gene Chr1:132841348-132856501 (+)



Homology
more
  • Human Ortholog
    FCMR, Fc mu receptor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FCMR, Fc mu receptor
  • Synonyms
    FAIM3, FcmuR, IgM FcR, TOSO
  • Links
    NCBI Gene ID: 9214
    neXtProt AC: NX_O60667
    UniProt: O60667

  • Chr Location
    1q32.1; chr1:206903317-206923247 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 4 alleles in 4 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for knock-out alleles exhibit a slight decrease in B cell numbers reduced sensitivity to Gal-induced liver damage, increased granulocyte production of ROS and increased sensitivity to infection by Listeria monocytogenes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69169 NCBI Gene Model | MGI Sequence Detail 15015 C57BL/6J ±  kb
    transcript NM_026976 RefSeq | MGI Sequence Detail 1492 C57BL/6  
    polypeptide A1KXC4 UniProt | EBI | MGI Sequence Detail 422 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 3
    References
    more
    • Summaries
      All 56
      Gene Ontology 8
      Phenotypes 27
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:338026 Mahmoudi Aliabadi P, et al., Enhanced Mott cell formation linked with IgM Fc receptor (FcmuR) deficiency. Eur J Immunol. 2023 Jul;53(7):e2250315
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory