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Rint1 Gene Detail
Summary
  • Symbol
    Rint1
  • Name
    RAD50 interactor 1
  • Synonyms
    1500019C06Rik, 2810450M21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916233
    NCBI Gene: 72772
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:23992709-24025367 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 10.45 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    371 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916233
 protein coding gene Chr5:23992700-24028582 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029332
 protein coding gene Chr5:21473989-21508570 (+)
A/J MGP_AJ_G0029298
 protein coding gene Chr5:20752953-20785366 (+)
AKR/J MGP_AKRJ_G0029249
 protein coding gene Chr5:21592531-21630197 (+)
BALB/cJ MGP_BALBcJ_G0029309
 protein coding gene Chr5:21261063-21295571 (+)
C3H/HeJ MGP_C3HHeJ_G0029029
 protein coding gene Chr5:21680897-21718830 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029762
 protein coding gene Chr5:22945321-22983844 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027000
 protein coding gene Chr5:18710999-18745738 (+)
CAST/EiJ MGP_CASTEiJ_G0028441
 protein coding gene Chr5:20865313-20896464 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0029147
 protein coding gene Chr5:21035504-21070204 (+)
FVB/NJ MGP_FVBNJ_G0029105
 protein coding gene Chr5:20425729-20460647 (+)
LP/J MGP_LPJ_G0029231
 protein coding gene Chr5:21858902-21895284 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029134
 protein coding gene Chr5:24451272-24491537 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029796
 protein coding gene Chr5:21194074-21236682 (+)
PWK/PhJ MGP_PWKPhJ_G0028164
 protein coding gene Chr5:20101332-20137750 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027996
 protein coding gene Chr5:20569215-20603966 (+)
WSB/EiJ MGP_WSBEiJ_G0028521
 protein coding gene Chr5:21287263-21323410 (+)



Homology
more
  • Human Ortholog
    RINT1, RAD50 interactor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RINT1, RAD50 interactor 1
  • Synonyms
    ILFS3, RINT-1
  • Links
    NCBI Gene ID: 60561
    neXtProt AC: NX_Q6NUQ1
    UniProt: Q6NUQ1

  • Chr Location
    7q22.3; chr7:105532169-105567677 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RINT1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a mutant allele exhibit early embryonic lethality. Mice heterozygous for a mutant allele exhibit premature death with a life span of 24 months and increased multiple tumor incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    43
  • cDNA Data
    18
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028999 Ensembl Gene Model | MGI Sequence Detail 32659 C57BL/6J ±  kb
    transcript ENSMUST00000030852 Ensembl | MGI Sequence Detail 3298 Not Applicable  
    polypeptide ENSMUSP00000030852 Ensembl | MGI Sequence Detail 792 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920022
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 23
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:309183 Gomes AL, et al., RINT1 Loss Impairs Retinogenesis Through TRP53-Mediated Apoptosis. Front Cell Dev Biol. 2020;8:711
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory