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Arv1 Gene Detail
Summary
  • Symbol
    Arv1
  • Name
    ARV1 homolog, fatty acid homeostasis modulator
  • Synonyms
    1110067L22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916115
    NCBI Gene: 68865
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:125448878-125460862 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916115
 protein coding gene Chr8:125448765-125469533 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034276
 protein coding gene Chr8:128426426-128438265 (+)
A/J MGP_AJ_G0034256
 protein coding gene Chr8:123105909-123117757 (+)
AKR/J MGP_AKRJ_G0034183
 protein coding gene Chr8:126650364-126662599 (+)
BALB/cJ MGP_BALBcJ_G0034249
 protein coding gene Chr8:123290617-123302449 (+)
C3H/HeJ MGP_C3HHeJ_G0033960
 protein coding gene Chr8:127297907-127310573 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034769
 protein coding gene Chr8:132712796-132725247 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031710
 protein coding gene Chr8:115868550-115880027 (+)
CAST/EiJ MGP_CASTEiJ_G0033287
 protein coding gene Chr8:127421856-127434655 (+)
CBA/J MGP_CBAJ_G0033933
 protein coding gene Chr8:137582215-137596510 (+)
DBA/2J MGP_DBA2J_G0034089
 protein coding gene Chr8:122261622-122273390 (+)
FVB/NJ MGP_FVBNJ_G0034033
 protein coding gene Chr8:121435906-121447665 (+)
LP/J MGP_LPJ_G0034178
 protein coding gene Chr8:128590516-128602394 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034080
 protein coding gene Chr8:139660613-139673956 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034788
 protein coding gene Chr8:126890682-126903468 (+)
PWK/PhJ MGP_PWKPhJ_G0032989
 protein coding gene Chr8:122024952-122037404 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032828
 protein coding gene Chr8:125519919-125531738 (+)
WSB/EiJ MGP_WSBEiJ_G0033404
 protein coding gene Chr8:127607946-127621496 (+)



Homology
more
  • Human Ortholog
    ARV1, ARV1 homolog, fatty acid homeostasis modulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARV1, ARV1 homolog, fatty acid homeostasis modulator
  • Synonyms
    DEE38, EIEE38
  • Links
    NCBI Gene ID: 64801
    neXtProt AC: NX_Q9H2C2
    UniProt: Q9H2C2

  • Chr Location
    1q42.2; chr1:230978981-231000733 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ARV1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    72 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show reduced survivor rate, seizures, increased food intake, hyperactivity and metabolic changes including lack of weight gain, improved glucose tolerance, elevated adiponectin secretion, increased energy expenditure, reduced white fat amount, and resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031982 Ensembl Gene Model | MGI Sequence Detail 11985 C57BL/6J ±  kb
    transcript ENSMUST00000034463 Ensembl | MGI Sequence Detail 1165 Not Applicable  
    polypeptide ENSMUSP00000034463 Ensembl | MGI Sequence Detail 266 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142557, MGI:2142764
    References
    more
    • Summaries
      All 34
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:263695 Gallo-Ebert C, et al., Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease. J Biol Chem. 2018 Apr 20;293(16):5956-5974
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory