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Ifitm1 Gene Detail
Summary
  • Symbol
    Ifitm1
  • Name
    interferon induced transmembrane protein 1
  • Synonyms
    1110036C17Rik, fragilis2, Mil2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915963
    NCBI Gene: 68713
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:140547342-140549740 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.20 cM, cytoband F5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915963
 protein coding gene Chr7:140547134-140549740 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033204
 protein coding gene Chr7:146106356-146108960 (+)
A/J MGP_AJ_G0033186
 protein coding gene Chr7:141950991-141953595 (+)
AKR/J MGP_AKRJ_G0033118
 protein coding gene Chr7:145846247-145848851 (+)
BALB/cJ MGP_BALBcJ_G0033187
 protein coding gene Chr7:141679071-141681675 (+)
C3H/HeJ MGP_C3HHeJ_G0032901
 protein coding gene Chr7:145602943-145605547 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033698
 protein coding gene Chr7:151453915-151456519 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030671
 protein coding gene Chr7:143162100-143165039 (+)
CAST/EiJ MGP_CASTEiJ_G0032231
 protein coding gene Chr7:137903159-137906156 (+)
CBA/J MGP_CBAJ_G0032873
 protein coding gene Chr7:156579523-156582127 (+)
DBA/2J MGP_DBA2J_G0033026
 protein coding gene Chr7:139889417-139892021 (+)
FVB/NJ MGP_FVBNJ_G0032978
 protein coding gene Chr7:139803071-139805675 (+)
LP/J MGP_LPJ_G0033120
 protein coding gene Chr7:147614803-147617407 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033011
 protein coding gene Chr7:157242476-157245080 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033718
 protein coding gene Chr7:144826717-144829321 (+)
PWK/PhJ MGP_PWKPhJ_G0031935
 protein coding gene Chr7:133165088-133168020 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031782
 protein coding gene Chr7:131647822-131650532 (+)
WSB/EiJ MGP_WSBEiJ_G0032342
 protein coding gene Chr7:145748673-145751276 (+)



Homology
more
  • Human Ortholog
    IFITM1, interferon induced transmembrane protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFITM1, interferon induced transmembrane protein 1
  • Synonyms
    9-27, CD225, DSPA2a, IFI17, LEU13
  • Links
    NCBI Gene ID: 8519
    neXtProt AC: NX_P13164
    UniProt: P13164

  • Chr Location
    11p15.5; chr11:310041-315272 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human IFITM1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 4 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibited enhanced motor coordination during inverted screen testing when compared with that of their wild-type littermates.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    9
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    979
  • Tissues
    125
  • cDNA Data
    51
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68713 NCBI Gene Model | MGI Sequence Detail 2399 C57BL/6J ±  kb
    transcript NM_001112715 RefSeq | MGI Sequence Detail 702 C57BL/6  
    polypeptide Q9D103 UniProt | EBI | MGI Sequence Detail 106 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR007593 CD225/Dispanin family
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 53
      Primer pair 6

      Microarray probesets 4
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 13
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
    • Latest
      J:332021 Campbell RA, et al., IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis. J Clin Invest. 2022 Dec 1;132(23)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory