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Tefm Gene Detail
Summary
  • Symbol
    Tefm
  • Name
    transcription elongation factor, mitochondrial
  • Synonyms
    1110002N22Rik, FLJ22729
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915800
    NCBI Gene: 68550
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:80027504-80033001 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 47.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915800
 protein coding gene Chr11:80027500-80033697 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018806
 protein coding gene Chr11:81281186-81287765 (-)
A/J MGP_AJ_G0018773
 protein coding gene Chr11:78158858-78164385 (-)
AKR/J MGP_AKRJ_G0018743
 protein coding gene Chr11:80505716-80511157 (-)
BALB/cJ MGP_BALBcJ_G0018746
 protein coding gene Chr11:78547547-78553043 (-)
C3H/HeJ MGP_C3HHeJ_G0018560
 protein coding gene Chr11:80553687-80559118 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019198
 protein coding gene Chr11:83775388-83780844 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016832
 protein coding gene Chr11:75090176-75096563 (-)
CAST/EiJ MGP_CASTEiJ_G0018115
 protein coding gene Chr11:81036288-81046631 (-)
CBA/J MGP_CBAJ_G0018531
 protein coding gene Chr11:87420776-87426262 (-)
DBA/2J MGP_DBA2J_G0018639
 protein coding gene Chr11:77715385-77720859 (-)
FVB/NJ MGP_FVBNJ_G0018628
 protein coding gene Chr11:77283567-77288980 (-)
LP/J MGP_LPJ_G0018709
 protein coding gene Chr11:81799386-81805288 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018655
 protein coding gene Chr11:87710390-87715882 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019238
 protein coding gene Chr11:80755309-80760724 (-)
PWK/PhJ MGP_PWKPhJ_G0017885
 protein coding gene Chr11:78518529-78528707 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017676
 protein coding gene Chr11:80346349-80351743 (-)
WSB/EiJ MGP_WSBEiJ_G0018167
 protein coding gene Chr11:80589540-80595028 (-)



Homology
more
  • Human Ortholog
    TEFM, transcription elongation factor, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TEFM, transcription elongation factor, mitochondrial
  • Synonyms
    C17orf42, COXPD58
  • Links
    NCBI Gene ID: 79736
    neXtProt AC: NX_Q96QE5
    UniProt: Q96QE5

  • Chr Location
    17q11.2; chr17:30897336-30906238 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TEFM associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced embryo size, absent heart tube and embryonic lethality at E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046909 Ensembl Gene Model | MGI Sequence Detail 5498 C57BL/6J ±  kb
    transcript ENSMUST00000050207 Ensembl | MGI Sequence Detail 1309 Not Applicable  
    polypeptide ENSMUSP00000059304 Ensembl | MGI Sequence Detail 364 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 30

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Gene Ontology 4
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:276874 Jiang S, et al., TEFM regulates both transcription elongation and RNA processing in mitochondria. EMBO Rep. 2019 Jun;20(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory