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Tada3 Gene Detail
Summary
  • Symbol
    Tada3
  • Name
    transcriptional adaptor 3
  • Synonyms
    1110004B19Rik, ADA3, Tada3l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915724
    NCBI Gene: 101206
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113343594-113354799 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915724
 protein coding gene Chr6:113342986-113354844 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031119
 protein coding gene Chr6:115882981-115894093 (-)
A/J MGP_AJ_G0031088
 protein coding gene Chr6:111443714-111454825 (-)
AKR/J MGP_AKRJ_G0031019
 protein coding gene Chr6:114435177-114446255 (-)
BALB/cJ MGP_BALBcJ_G0031099
 protein coding gene Chr6:111389575-111400682 (-)
C3H/HeJ MGP_C3HHeJ_G0030609
 protein coding gene Chr6:69849705-69861831 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031558
 protein coding gene Chr6:118888381-118899483 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028722
 protein coding gene Chr6:108444084-108455448 (-)
CAST/EiJ MGP_CASTEiJ_G0030206
 protein coding gene Chr6:114873434-114884845 (-)
CBA/J MGP_CBAJ_G0030785
 protein coding gene Chr6:123580237-123591312 (-)
DBA/2J MGP_DBA2J_G0030938
 protein coding gene Chr6:110522943-110534011 (-)
FVB/NJ MGP_FVBNJ_G0030892
 protein coding gene Chr6:109522200-109533331 (-)
LP/J MGP_LPJ_G0031018
 protein coding gene Chr6:115920740-115931844 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030926
 protein coding gene Chr6:127846829-127857943 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031585
 protein coding gene Chr6:114446887-114458059 (-)
PWK/PhJ MGP_PWKPhJ_G0029922
 protein coding gene Chr6:109475333-109487598 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029750
 protein coding gene Chr6:113265967-113277027 (-)
WSB/EiJ MGP_WSBEiJ_G0030290
 protein coding gene Chr6:114825782-114837107 (-)



Homology
more
  • Human Ortholog
    TADA3, transcriptional adaptor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TADA3, transcriptional adaptor 3
  • Synonyms
    ADA3, hADA3, NGG1, STAF54, TADA3L
  • Links
    NCBI Gene ID: 10474
    neXtProt AC: NX_O75528
    UniProt: O75528

  • Chr Location
    3p25.3; chr3:9779967-9793011 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality between E3.5 and E8.5 associated with impaired proliferation of trophoblast cells and absence of inner cell mass.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    16
  • cDNA Data
    81
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 101206 NCBI Gene Model | MGI Sequence Detail 11206 C57BL/6J ±  kb
    transcript NM_001372392 RefSeq | MGI Sequence Detail 2249 C57BL/6  
    polypeptide Q8R0L9 UniProt | EBI | MGI Sequence Detail 432 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 81

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141524
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 2
      Gene Ontology 16
      Phenotypes 11
    • Earliest
      J:320277 Ogryzko VV, et al., Histone-like TAFs within the PCAF histone acetylase complex. Cell. 1998 Jul 10;94(1):35-44
    • Latest
      J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory