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Tmem174 Gene Detail
Summary
  • Symbol
    Tmem174
  • Name
    transmembrane protein 174
  • Synonyms
    0610009B10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915594
    NCBI Gene: 68344
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:98771486-98773918 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 52.11 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915594
 protein coding gene Chr13:98771486-98773918 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020868
 protein coding gene Chr13:100368454-100370886 (-)
A/J MGP_AJ_G0020822
 protein coding gene Chr13:96539519-96541957 (-)
AKR/J MGP_AKRJ_G0020796
 protein coding gene Chr13:99488315-99490741 (-)
BALB/cJ MGP_BALBcJ_G0020820
 protein coding gene Chr13:97247742-97250180 (-)
C3H/HeJ MGP_C3HHeJ_G0020611
 protein coding gene Chr13:99228603-99231041 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021254
 protein coding gene Chr13:103381424-103383856 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018823
 protein coding gene Chr13:92268636-92271061 (-)
CAST/EiJ MGP_CASTEiJ_G0020129
 protein coding gene Chr13:98590909-98593362 (-)
CBA/J MGP_CBAJ_G0020571
 protein coding gene Chr13:107484264-107486690 (-)
DBA/2J MGP_DBA2J_G0020696
 protein coding gene Chr13:96307414-96309840 (-)
FVB/NJ MGP_FVBNJ_G0020677
 protein coding gene Chr13:95058455-95060893 (-)
LP/J MGP_LPJ_G0020771
 protein coding gene Chr13:100471262-100473694 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020705
 protein coding gene Chr13:107816998-107819436 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021295
 protein coding gene Chr13:98931233-98933671 (-)
PWK/PhJ MGP_PWKPhJ_G0019882
 protein coding gene Chr13:95115377-95117830 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019705
 protein coding gene Chr13:95217273-95219728 (-)
WSB/EiJ MGP_WSBEiJ_G0020187
 protein coding gene Chr13:99378053-99380491 (-)



Homology
more
  • Human Ortholog
    TMEM174, transmembrane protein 174
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM174, transmembrane protein 174
  • Links
    NCBI Gene ID: 134288
    neXtProt AC: NX_Q8WUU8
    UniProt: Q8WUU8

  • Chr Location
    5q13.2; chr5:73173193-73175143 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit hyperphosphatemia and vascular calcification.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    16
  • cDNA Data
    48
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68344 NCBI Gene Model | MGI Sequence Detail 2433 C57BL/6J ±  kb
    transcript NM_026685 RefSeq | MGI Sequence Detail 2252 C57BL/6  
    polypeptide Q9DCX7 UniProt | EBI | MGI Sequence Detail 243 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 48
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2145177
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:328157 Miyazaki-Anzai S, et al., Targeted Disruption of a Proximal Tubule-Specific TMEM174 Gene in Mice Causes Hyperphosphatemia and Vascular Calcification. J Am Soc Nephrol. 2022 Aug;33(8):1477-1486
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory