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Babam1 Gene Detail
Summary
  • Symbol
    Babam1
  • Name
    BRISC and BRCA1 A complex member 1
  • Synonyms
    5430437P03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915501
    NCBI Gene: 68251
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71849505-71857263 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.43 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915501
protein coding gene Chr8:71848809-71857416 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033743
protein coding gene Chr8:71787872-71795733 (+)
A/J MGP_AJ_G0033726
protein coding gene Chr8:68868241-68876093 (+)
AKR/J MGP_AKRJ_G0033651
protein coding gene Chr8:70887687-70900371 (+)
BALB/cJ MGP_BALBcJ_G0033722
protein coding gene Chr8:69034585-69042513 (+)
C3H/HeJ MGP_C3HHeJ_G0033432
protein coding gene Chr8:71472261-71480168 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034240
protein coding gene Chr8:74529169-74537084 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031182
protein coding gene Chr8:63504714-63512394 (+)
CAST/EiJ MGP_CASTEiJ_G0032757
protein coding gene Chr8:70926474-70938283 (+)
CBA/J MGP_CBAJ_G0033410
protein coding gene Chr8:77149420-77162860 (+)
DBA/2J MGP_DBA2J_G0033564
protein coding gene Chr8:68597574-68605563 (+)
FVB/NJ MGP_FVBNJ_G0033506
protein coding gene Chr8:67674707-67685629 (+)
LP/J MGP_LPJ_G0033651
protein coding gene Chr8:71764459-71773907 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033553
protein coding gene Chr8:79728055-79735979 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034257
protein coding gene Chr8:70958559-70968207 (+)
PWK/PhJ MGP_PWKPhJ_G0032464
protein coding gene Chr8:67869131-67877666 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032301
protein coding gene Chr8:69920341-69928200 (+)
WSB/EiJ MGP_WSBEiJ_G0032872
protein coding gene Chr8:71308046-71317310 (+)



Homology
more
  • Human Ortholog
    BABAM1, BRISC and BRCA1 A complex member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BABAM1, BRISC and BRCA1 A complex member 1
  • Synonyms
    C19orf62, HSPC142, MERIT40, NBA1
  • Links
    NCBI Gene ID: 29086
    neXtProt AC: NX_Q9NWV8
    UniProt: Q9NWV8

  • Chr Location
    19p13.11; chr19:17267376-17281249 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show thrombocytosis and increased hematopoietic stem cell (HSC) number. HSCs are more resistant to cytotoxic stress and show increased quiescence, decelerated cell cycle kinetics, and enhanced repopulating ability and self-renewal upon serial transplantation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031820 Ensembl Gene Model | MGI Sequence Detail 7759 C57BL/6J ±  kb
    transcript ENSMUST00000002473 Ensembl | MGI Sequence Detail 1433 Not Applicable  
    polypeptide ENSMUSP00000002473 Ensembl | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 124
      cDNA 124

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:275430 Donaghy R, et al., The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination. Blood. 2019 Apr 4;133(14):1560-1571

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory